| Lu, J;Yu, J;Liu, P;Gu, J;Chen, Y;Zhang, T;Li, J;Wang, T;Yang, W;Lin, R;Wang, F;Qi, M;Li, T;Liu, Y; Ubiquitin-mediated degradation of SlPsbS regulates low night temperature tolerance in tomatoes Cell reports 2024-09-19 [PMID: 39302836] (Bioassay, E. coli) |
Bioassay |
E. coli |
| Zhang, R;Wu, Y;Qu, X;Yang, W;Wu, Q;Huang, L;Jiang, Q;Ma, J;Zhang, Y;Qi, P;Chen, G;Jiang, Y;Zheng, Y;Wang, X;Wei, Y;Xu, Q; The RING-finger ubiquitin E3 ligase TaPIR1 targets TaHRP1 for degradation to suppress chloroplast function Nature communications 2024-08-12 [PMID: 39134523] (Bioassay, N/A) |
Bioassay |
N/A |
| Alcón, P;Kaczmarczyk, AP;Ray, KK;Liolios, T;Guilbaud, G;Sijacki, T;Shen, Y;McLaughlin, SH;Sale, JE;Knipscheer, P;Rueda, DS;Passmore, LA; FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions Nature 2024-08-01 [PMID: 39085614] (Bioassay, Human) |
Bioassay |
Human |
| Kubori, T;Arasaki, K;Oide, H;Kitao, T;Nagai, H; Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics eLife 2024-05-21 [PMID: 38771316] (Bioassay, N/A) |
Bioassay |
N/A |
| Radko-Juettner, S;Yue, H;Myers, JA;Carter, RD;Robertson, AN;Mittal, P;Zhu, Z;Hansen, BS;Donovan, KA;Hunkeler, M;Rosikiewicz, W;Wu, Z;McReynolds, MG;Roy Burman, SS;Schmoker, AM;Mageed, N;Brown, SA;Mobley, RJ;Partridge, JF;Stewart, EA;Pruett-Miller, SM;Nabet, B;Peng, J;Gray, NS;Fischer, ES;Roberts, CWM; Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF Nature 2024-03-27 [PMID: 38538798] (Bioassay, N/A) |
Bioassay |
N/A |
| Wu, S;Hu, C;Zhu, C;Fan, Y;Zhou, J;Xia, X;Shi, K;Zhou, Y;Foyer, CH;Yu, J; The MYC2-PUB22-JAZ4 module plays a crucial role in jasmonate signaling in tomato Molecular plant 2024-02-09 [PMID: 38341757] (Bioassay, N/A) |
Bioassay |
N/A |
| Olazabal-Herrero, A;He, B;Kwon, Y;Gupta, AK;Dutta, A;Huang, Y;Boddu, P;Liang, Z;Liang, F;Teng, Y;Lan, L;Chen, X;Pei, H;Pillai, MM;Sung, P;Kupfer, GM; The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export Cell reports 2024-01-23 [PMID: 38165804] (Bioassay, N/A) |
Bioassay |
N/A |
| Sabri, N;Cuneo, MJ;Marzahn, MR;Lee, J;Bouchard, JJ;Güllülü, Ö;Vaithiyalingam, S;Borgia, MB;Schmit, J;Mittag, T; Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP The Journal of biological chemistry 2023-11-04 [PMID: 37926283] (Ubiquitination, Human) |
Ubiquitination |
Human |
| Xu, Y;Qu, M;He, Y;He, Q;Shen, T;Luo, J;Tan, D;Bao, H;Xu, C;Ji, X;Hu, X;Barkat, MQ;Zeng, LH;Wu, X; Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions The Journal of biological chemistry 2023-10-25 [PMID: 37890777] (Bioassay, N/A) |
Bioassay |
N/A |
| Li, P;Zhen, Y;Kim, C;Liu, Z;Hao, J;Deng, H;Deng, H;Zhou, M;Wang, XD;Qin, T;Yu, Y; Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer Science advances 2023-10-27 [PMID: 37878693] (Bioassay, Human) |
Bioassay |
Human |
| VanDyke, D;Xu, L;Sargunas, PR;Gilbreth, RN;Baca, M;Gao, C;Hunt, J;Spangler, JB; Redirecting the specificity of tripartite motif containing-21 scaffolds using a novel discovery and design approach The Journal of biological chemistry 2023-10-20 [PMID: 37866632] (Bioassay, N/A) |
Bioassay |
N/A |
| Sun, J;Huang, S;Lu, Q;Li, S;Zhao, S;Zheng, X;Zhou, Q;Zhang, W;Li, J;Wang, L;Zhang, K;Zheng, W;Feng, X;Liu, B;Kong, F;Xiang, F; UV-B irradiation-activated E3 ligase GmILPA1 modulates gibberellin catabolism to increase plant height in soybean Nature communications 2023-10-07 [PMID: 37805547] (Bioassay, N/A) |
Bioassay |
N/A |
| Li, Y;Bao, L;Zheng, H;Geng, M;Chen, T;Dai, X;Xiao, H;Yang, L;Mao, C;Qiu, Y;Xu, Y;Wang, D;Li, MX;Chen, Q; E3 ubiquitin ligase TRIM21 targets TIF1? to regulate ?-catenin signaling in glioblastoma Theranostics 2023-09-04 [PMID: 37771771] (Bioassay, N/A) |
Bioassay |
N/A |
| Meyers, M;Cismoski, S;Panidapu, A;Chie-Leon, B;Nomura, DK; Targeted Protein Degradation through Recruitment of the CUL4A Complex Adaptor Protein DDB1 bioRxiv : the preprint server for biology 2023-08-12 [PMID: 37614621] (Bioassay, N/A) |
Bioassay |
N/A |
| Yan, W;Zhong, Y;Hu, X;Xu, T;Zhang, Y;Kales, S;Qu, Y;Talley, DC;Baljinnyam, B;LeClair, CA;Simeonov, A;Polster, BM;Huang, R;Ye, Y;Rai, G;Henderson, MJ;Tao, D;Fang, S; Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes Nature communications 2023-08-09 [PMID: 37558718] (Bioassay, N/A) |
Bioassay |
N/A |
| Li, Y;Wang, H;Sun, B;Su, G;Cang, Y;Zhao, L;Zhao, S;Li, Y;Mao, B;Ma, P; Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma Cell death & disease 2023-08-03 [PMID: 37537194] (Bioassay, N/A) |
Bioassay |
N/A |
| Fang, Z;Li, X;Yoshino, Y;Suzuki, M;Qi, H;Murooka, H;Katakai, R;Shirota, M;Mai Pham, TA;Matsuzawa, A;Otsuka, K;Ishioka, C;Mori, T;Chiba, N; Aurora A polyubiquitinates the BRCA1-interacting protein OLA1 to promote centrosome maturation Cell reports 2023-07-21 [PMID: 37481721] (Bioassay, Human) |
Bioassay |
Human |
| Chen, M;Wang, K;Han, Y;Yan, S;Yuan, H;Liu, Q;Li, L;Li, N;Zhu, H;Lu, D;Wang, K;Liu, F;Luo, D;Zhang, Y;Jiang, J;Li, D;Zhang, L;Ji, H;Zhou, H;Chen, Y;Qin, J;Gao, D; Identification of XAF1 as an endogenous AKT inhibitor Cell reports 2023-06-27 [PMID: 37384528] (Bioassay, N/A) |
Bioassay |
N/A |
| R Zhou, J Chen, Y Xu, Y Ye, G Zhong, T Chen, L Qiu PRPF19 facilitates colorectal cancer liver metastasis through activation of the Src-YAP1 pathway via K63-linked ubiquitination of MYL9 Cell Death & Disease, 2023-04-08;14(4):258. 2023-04-08 [PMID: 37031206] (Bioassay, Human) |
Bioassay |
Human |
| X Xu, CW Chang, M Li, K Omabe, N Le, YH Chen, F Liang, Y Liu DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation Nature Communications, 2023-03-04;14(1):1233. 2023-03-04 [PMID: 36871012] (Ubiquitination, Human) |
Ubiquitination |
Human |
| X Xu, CW Chang, M Li, K Omabe, N Le, YH Chen, F Liang, Y Liu DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation Nature Communications, 2023;14(1):1233. 2023 [PMID: 36871012] (Ubiquitination, Human) |
Ubiquitination |
Human |
| M Gingerich, J Zhu, B Chai, M Vincent, N Xie, V Sidarala, N Kotov, D Sahu, D Klionsky, S Schnell, S Soleimanpo Reciprocal regulatory balance within the CLEC16A-RNF41 mitophagy complex depends on an intrinsically disordered protein region The Journal of Biological Chemistry, 2023-02-22;0(0):103057. 2023-02-22 [PMID: 36822331] (Bioassay, N/A) |
Bioassay |
N/A |
| TET Mevissen, AV Prasad, JC Walter TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away Cell Reports, 2023-02-18;42(2):112125. 2023-02-18 [PMID: 36807144] (Bioassay, N/A) |
Bioassay |
N/A |
| K Best, K Ikeuchi, L Kater, D Best, J Musial, Y Matsuo, O Berninghau, T Becker, T Inada, R Beckmann Structural basis for clearing of ribosome collisions by the RQT complex Nature Communications, 2023-02-17;14(1):921. 2023-02-17 [PMID: 36801861] (Bioassay, N/A) |
Bioassay |
N/A |
| X Du, J Pang, B Gu, T Si, Y Chang, T Li, M Wu, Z Wang, Y Wang, J Feng, N Wu, J Man, H Li, A Li, T Zhang, B Wang, X Duan A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma Nucleic Acids Research, 2023-02-22;0(0):. 2023-02-22 [PMID: 36660824] (Bioassay, N/A) |
Bioassay |
N/A |
| W Wei, YY Yang, JY Chen, P Lakshmanan, JF Kuang, WJ Lu, W Shan MaNAC029 modulates ethylene biosynthesis and fruit quality and undergoes MaXB3-mediated proteasomal degradation during banana ripening Journal of advanced research, 2022;0(0):. 2022 [PMID: 36529351] (Bioassay, Human) |
Bioassay |
Human |
| W Wei, YY Yang, JY Chen, P Lakshmanan, JF Kuang, WJ Lu, W Shan MaNAC029 modulates ethylene biosynthesis and fruit quality and undergoes MaXB3-mediated proteasomal degradation during banana ripening Journal of advanced research, 2022-12-15;0(0):. 2022-12-15 [PMID: 36529351] (Bioassay, Human) |
Bioassay |
Human |
| LT Lin, YS Lu, HH Huang, H Chen, SW Hsu, LK Chang Regulation of Epstein-Barr Virus Minor Capsid Protein BORF1 by TRIM5alpha International Journal of Molecular Sciences, 2022;23(23):. 2022 [PMID: 36499678] (Bioassay, Human) |
Bioassay |
Human |
| LT Lin, YS Lu, HH Huang, H Chen, SW Hsu, LK Chang Regulation of Epstein-Barr Virus Minor Capsid Protein BORF1 by TRIM5alpha International Journal of Molecular Sciences, 2022-12-05;23(23):. 2022-12-05 [PMID: 36499678] (Bioassay, Human) |
Bioassay |
Human |
| TT Liu, H Yang, FF Zhuo, Z Yang, MM Zhao, Q Guo, Y Liu, D Liu, KW Zeng, PF Tu Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy EBioMedicine, 2022-11-11;86(0):104353. 2022-11-11 [PMID: 36375317] (Bioassay, Human) |
Bioassay |
Human |
| OV Kochenova, S Mukkavalli, M Raman, JC Walter Cooperative assembly of p97 complexes involved in replication termination Nature Communications, 2022-11-03;13(1):6591. 2022-11-03 [PMID: 36329031] (Bioassay, Human) |
Bioassay |
Human |
| F Laneri, S García-Viñ, V Lanza, N Licciardel, D Milardi, S Sortino, G Grasso Dipyridamole for tracking amyloidogenic proteins aggregation and enhancing polyubiquitination Archives of biochemistry and biophysics, 2022-07-19;728(0):109354. 2022-07-19 [PMID: 35863477] (Bioassay, Human) |
Bioassay |
Human |
| X Ma, X Ma, L Zhu, Y Zhao, M Chen, T Li, Y Lin, D Ma, C Sun, L Han The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling Oncogenesis, 2022-07-20;11(1):40. 2022-07-20 [PMID: 35858925] (Bioassay, Human) |
Bioassay |
Human |
| L Lao, I Bourdeau, L Gagliardi, X He, W Shi, B Hao, M Tan, Y Hu, J Peng, B Coulombe, DJ Torpy, HS Scott, A Lacroix, H Luo, J Wu ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia Nucleic Acids Research, 2022-06-24;0(0):. 2022-06-24 [PMID: 35687106] (Bioassay, Human) |
Bioassay |
Human |
| SK Pirooznia, H Wang, N Panicker, M Kumar, S Neifert, MA Dar, E Lau, BG Kang, J Redding-Oc, JC Troncoso, VL Dawson, TM Dawson Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease Science Advances, 2022-04-01;8(13):eabh1824. 2022-04-01 [PMID: 35363524] (Bioassay, N/A) |
Bioassay |
N/A |
| Y Zhou, R Zheng, S Liu, C Disoma, A Du, S Li, Z Chen, Z Dong, Y Zhang, S Li, P Liu, A Razzaq, X Chen, Y Liao, S Tao, Y Liu, L Xu, Q Zhang, J Peng, X Deng, S Li, T Jiang, Z Xia Host E3 ligase HUWE1 attenuates the pro-apoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation The Journal of Biological Chemistry, 2022-01-13;0(0):101584. 2022-01-13 [PMID: 35032548] (Bioassay, Human) |
Bioassay |
Human |
| S Yoon, K Bogdanov, D Wallach Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes Cell Death and Differentiation, 2022-01-09;0(0):. 2022-01-09 [PMID: 34999730] (Bioassay, Human) |
Bioassay |
Human |
| M Won, KA Park, S Kim, E Ju, Y Ko, H Yoo, H Ro, J Lee, J Oh, EG Lee, SY Kim, SW Nam, HM Shen, MK Yeo, JM Kim, GM Hur ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-kappaB Cell Death and Differentiation, 2021-11-27;0(0):. 2021-11-27 [PMID: 34839354] (Bioassay, Human) |
Bioassay |
Human |
| T Mahlokozer, B Patel, H Chen, P Desouza, X Qu, DD Mao, D Hafez, W Yang, R Taiwo, M Paturu, A Salehi, AD Gujar, GP Dunn, N Mosammapar, AA Petti, H Yano, AH Kim Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma Nature Communications, 2021-11-03;12(1):6321. 2021-11-03 [PMID: 34732716] (Bioassay, Human) |
Bioassay |
Human |
| RK Manne, Y Agrawal, SK Malonia, S Banday, S Edachery, A Patel, A Kumar, P Shetty, MK Santra FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX The Journal of Biological Chemistry, 2021-09-26;0(0):101253. 2021-09-26 [PMID: 34587475] (Bioassay, Human) |
Bioassay |
Human |
| Y Liu, C Qin, Y Rao, C Ngo, JJ Feng, J Zhao, S Zhang, TY Wang, J Carriere, AC Savas, M Zarinfar, S Rice, H Yang, W Yuan, JA Camarero, J Yu, XS Chen, C Zhang, P Feng SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response MBio, 2021-09-21;0(0):e0233521. 2021-09-21 [PMID: 34544279] (Bioassay, E. coli, Human) |
Bioassay |
E. coli, Human |
| G Kokic, FR Wagner, A Chernev, H Urlaub, P Cramer Structural basis of human transcription-DNA repair coupling Nature, 2021-09-15;0(0):. 2021-09-15 [PMID: 34526721] (Bioassay, Human) |
Bioassay |
Human |
| C Shen, A Nayak, LR Neitzel, AA Adams, M Silver-Ise, LM Sawyer, H Benchabane, H Wang, N Bunnag, B Li, DT Wynn, F Yang, M Garcia-Con, CH Williams, S Dakshanamu, CC Hong, NG Ayad, AJ Capobianco, Y Ahmed, E Lee, DJ Robbins The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling Nature Communications, 2021-09-06;12(1):5263. 2021-09-06 [PMID: 34489457] (Bioassay, Human) |
Bioassay |
Human |
| Y Sun, J Chen, SN Huang, YP Su, W Wang, K Agama, S Saha, LM Jenkins, JM Pascal, Y Pommier PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation Nature Communications, 2021-08-18;12(1):5010. 2021-08-18 [PMID: 34408146] (Bioassay) |
Bioassay |
|
| CW Davies, SE Vidal, L Phu, J Sudhamsu, TB Hinkle, S Chan Rosen, FR Schumacher, YJ Zeng, C Schwerdtfe, AS Peterson, JR Lill, CM Rose, AS Shaw, IE Wertz, DS Kirkpatric, JT Koerber Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W Nature Communications, 2021-07-29;12(1):4608. 2021-07-29 [PMID: 34326324] (Bioassay, Human) |
Bioassay |
Human |
| S Shukla, W Ying, F Gray, Y Yao, ML Simes, Q Zhao, H Miao, HJ Cho, P González-A, A Winkler, G Lund, T Purohit, E Kim, X Zhang, JM Ray, S He, C Nikolaidis, J Ndoj, J Wang, ? Jaremko, M Jaremko, RJH Ryan, ML Guzman, J Grembecka, T Cierpicki Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain Nature Chemical Biology, 2021-06-21;17(7):784-793. 2021-06-21 [PMID: 34155404] (Ubiquitination, Human) |
Ubiquitination |
Human |
| NM McCormack, MB Abera, ES Arnold, RM Gibbs, SE Martin, E Buehler, YC Chen, L Chen, KH Fischbeck, BG Burnett A high-throughput genome-wide RNAi screen identifies modifiers of survival motor neuron protein Cell Reports, 2021-05-11;35(6):109125. 2021-05-11 [PMID: 33979606] (Bioassay, Human) |
Bioassay |
Human |
| D Simoneschi, G Rona, N Zhou, YT Jeong, S Jiang, G Milletti, AA Arbini, A O'Sullivan, AA Wang, S Nithikasem, S Keegan, Y Siu, V Cianfanell, E Maiani, F Nazio, F Cecconi, F Boccalatte, D Fenyö, DR Jones, L Busino, M Pagano CRL4AMBRA1 is a master regulator of D-type cyclins Nature, 2021-04-14;592(7856):789-793. 2021-04-14 [PMID: 33854235] (Bioassay, Human) |
Bioassay |
Human |
| JK Barrows, G Fullbright, DT Long BRCA1-BARD1 regulates transcription through BRD4 in Xenopus nucleoplasmic extract Nucleic Acids Research, 2021-04-06;0(0):. 2021-04-06 [PMID: 33660782] (Ubiquitination, N/A) |
Ubiquitination |
N/A |
| MC Liebl, J Moehlenbri, H Becker, G Raddatz, SK Abdeen, RI Aqeilan, F Lyko, TG Hofmann DAZAP2 acts as specifier of the p53 response to DNA damage Nucleic Acids Research, 2021-03-18;0(0):. 2021-03-18 [PMID: 33591310] (Ubiquitination, Human) |
Ubiquitination |
Human |
| D Huang, Q Li, X Sun, X Sun, Y Tang, Y Qu, D Liu, T Yu, G Li, T Tong, Y Zhang CRL4DCAF8 dependent opposing stability control over the chromatin remodeler LSH orchestrates epigenetic dynamics in ferroptosis Cell Death and Differentiation, 2020-12-07;0(0):. 2020-12-07 [PMID: 33288900] (Bioassay, Human) |
Bioassay |
Human |
| XY Lu, XJ Shi, A Hu, JQ Wang, Y Ding, W Jiang, M Sun, X Zhao, J Luo, W Qi, BL Song Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis Nature, 2020-11-11;0(0):. 2020-11-11 [PMID: 33177714] (Bioassay, Complex Species Category) |
Bioassay |
Complex Species Category |
| MC Albert, K Brinkmann, W Pokrzywa, SD Günther, M Krönke, T Hoppe, H Kashkar CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage Cell Death & Disease, 2020-09-10;11(9):740. 2020-09-10 [PMID: 32913203] (Ubiquitylation, Human) |
Ubiquitylation |
Human |
| M Gatti, R Imhof, Q Huang, M Baudis, M Altmeyer The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency Cell Rep, 2020-08-04;32(5):107985. 2020-08-04 [PMID: 32755579] (Bioassay, Human) |
Bioassay |
Human |
| M S?abicki, Z Kozicka, G Petzold, YD Li, M Manojkumar, RD Bunker, KA Donovan, QL Sievers, J Koeppel, D Suchyta, AS Sperling, EC Fink, JA Gasser, LR Wang, SM Corsello, RS Sellar, M Jan, D Gillingham, C Scholl, S Fröhling, TR Golub, ES Fischer, NH Thomä, BL Ebert The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K Nature, 2020-06-03;0(0):. 2020-06-03 [PMID: 32494016] (Bioassay, N/A) |
Bioassay |
N/A |
| ME Matyskiela, T Clayton, X Zheng, C Mayne, E Tran, A Carpenter, B Pagarigan, J McDonald, M Rolfe, LG Hamann, G Lu, PP Chamberlai Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex Nat. Struct. Mol. Biol., 2020-04-06;27(4):319-322. 2020-04-06 [PMID: 32251415] (Ubiquitination, Spodoptera frugiperda) |
Ubiquitination |
Spodoptera frugiperda |
| YS Yoo, YJ Park, HS Lee, NTK Oanh, MY Cho, J Heo, ES Lee, H Cho, YY Park, H Cho Mitochondria ubiquitin ligase, MARCH5 resolves hepatitis B virus X protein aggregates in the liver pathogenesis Cell Death Dis, 2019-12-09;10(12):938. 2019-12-09 [PMID: 31819032] (Bioassay, Human) |
Bioassay |
Human |
| TC Ting, M Goralski, K Klein, B Wang, J Kim, Y Xie, D Nijhawan Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15 Cell Rep, 2019-11-05;29(6):1499-1510.e6. 2019-11-05 [PMID: 31693891] (Bioassay, Human) |
Bioassay |
Human |
| J Sitz, SA Blanchet, SF Gameiro, E Biquand, TM Morgan, M Galloy, J Dessapt, EG Lavoie, A Blondeau, BC Smith, JS Mymryk, CA Moody, A Fradet-Tur Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response Proc. Natl. Acad. Sci. U.S.A., 2019-09-09;116(39):19552-19562. 2019-09-09 [PMID: 31501315] (Bioassay, Virus - HPV) |
Bioassay |
Virus - HPV |
| RM Vaughan, SB Rothbart, BM Dickson The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for maintaining�DNA methylation J. Biol. Chem., 2019-09-03;0(0):. 2019-09-03 [PMID: 31481468] (Bioassay, Human) |
Bioassay |
Human |
| P Wang, F Yan, Z Li, Y Yu, SE Parnell, Y Xiong Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development J. Clin. Invest., 2019-07-25;130(0):. 2019-07-25 [PMID: 31343991] (Bioassay, Human) |
Bioassay |
Human |
| P Ma, NN Song, Y Li, Q Zhang, L Zhang, L Zhang, Q Kong, L Ma, X Yang, B Ren, C Li, X Zhao, Y Li, Y Xu, X Gao, YQ Ding, B Mao Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning Cell Rep, 2019-07-09;28(2):541-553.e4. 2019-07-09 [PMID: 31291587] (Bioassay) |
Bioassay |
|
| F Liang, AS Miller, S Longerich, C Tang, D Maranon, EA Williamson, R Hromas, C Wiese, GM Kupfer, P Sung DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response Nat Commun, 2019-06-28;10(1):2849. 2019-06-28 [PMID: 31253762] (Bioassay, Human) |
Bioassay |
Human |
| M Di Rienzo, M Antonioli, C Fusco, Y Liu, M Mari, I Orhon, G Refolo, F Germani, M Corazzari, A Romagnoli, F Ciccosanti, B Mandriani, MT Pellico, R De La Torr, H Ding, M Dentice, M Neri, A Ferlini, F Reggiori, M Kulesz-Mar, M Piacentini, G Merla, GM Fimia Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains Sci Adv, 2019-05-08;5(5):eaau8857. 2019-05-08 [PMID: 31123703] (Ubiquitination, Human) |
Ubiquitination |
Human |
| Q Yin, T Han, B Fang, G Zhang, C Zhang, ER Roberts, V Izumi, M Zheng, S Jiang, X Yin, M Kim, J Cai, EB Haura, JM Koomen, KSM Smalley, L Wan K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling Nat Commun, 2019-04-23;10(1):1870. 2019-04-23 [PMID: 31015455] (Ubiquitination, Human) |
Ubiquitination |
Human |
| MCJ Yip, AFA Keszei, Q Feng, V Chu, MJ McKenna, S Shao Mechanism for recycling tRNAs on stalled ribosomes Nat. Struct. Mol. Biol., 2019-04-22;0(0):. 2019-04-22 [PMID: 31011209] (Ubiquitination, Human) |
Ubiquitination |
Human |
| G Lu, J Yi, A Gubas, YT Wang, Y Wu, Y Ren, M Wu, Y Shi, C Ouyang, HWS Tan, T Wang, L Wang, ND Yang, S Deng, D Xia, RH Chen, SA Tooze, HM Shen Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation Autophagy, 2019-03-30;0(0):1-18. 2019-03-30 [PMID: 30898011] (Bioassay) |
Bioassay |
|
| Z Liang, F Liang, Y Teng, X Chen, J Liu, S Longerich, T Rao, AM Green, NB Collins, Y Xiong, L Lan, P Sung, GM Kupfer Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination Cell Rep, 2019-01-15;26(3):564-572.e5. 2019-01-15 [PMID: 30650351] (Bioassay) |
Bioassay |
|
| B Liu, J Yi, X Yang, L Liu, X Lou, Z Zhang, H Qi, Z Wang, J Zou, WG Zhu, W Gu, J Luo MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner Oncogene, 2018-12-07;0(0):. 2018-12-07 [PMID: 30532073] (Bioassay, Human) |
Bioassay |
Human |
| Y Dong, S Zhang, Z Wu, X Li, WL Wang, Y Zhu, S Stoilova-M, Y Lu, D Finley, Y Mao Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome Nature, 2018-11-12;0(0):. 2018-11-12 [PMID: 30479383] (Bioassay, Human) |
Bioassay |
Human |
| JM Lee, SS Choi, YH Lee, KW Khim, S Yoon, BG Kim, D Nam, PG Suh, K Myung, JH Choi The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasome-mediated degradation of PPAR? Exp. Mol. Med., 2018-10-15;50(10):135. 2018-10-15 [PMID: 30323259] (Ubiquitination, Human) |
Ubiquitination |
Human |
| X Huang, XN Wang, XD Yuan, WY Wu, PE Lobie, Z Wu XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation Oncogene, 2018-10-01;0(0):. 2018-10-01 [PMID: 30275562] (Bioassay, Human) |
Bioassay |
Human |
| ME Matyskiela, S Couto, X Zheng, G Lu, J Hui, K Stamp, C Drew, Y Ren, M Wang, A Carpenter, CW Lee, T Clayton, W Fang, CC Lu, M Riley, P Abdubek, K Blease, J Hartke, G Kumar, R Vessey, M Rolfe, LG Hamann, PP Chamberlai SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate Nat. Chem. Biol., 2018-09-06;0(0):. 2018-09-06 [PMID: 30190590] (Ubiquitination, Human) |
Ubiquitination |
Human |
| F Lampert, D Stafa, A Goga, MV Soste, S Gilberto, N Olieric, P Picotti, M Stoffel, M Peter The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation Elife, 2018-06-18;7(0):. 2018-06-18 [PMID: 29911972] (Bioassay, Human) |
Bioassay |
Human |
| S Ito, A Ueno, T Ueda, H Nakagawa, H Taniguchi, N Kayukawa, A Fujihara-I, F Hongo, K Okihara, O Ukimura CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells Oncotarget, 2018-04-03;9(25):17645-17655. 2018-04-03 [PMID: 29707137] (Bioassay) |
Bioassay |
|
| R Khanna, V Krishnamoo, VK Parnaik E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins FEBS J., 2018-05-03;0(0):. 2018-05-03 [PMID: 29676528] (Bioassay, Human) |
Bioassay |
Human |
| GS Hewawasam, K Dhatchinam, M Mattingly, C Seidel, JL Gerton Chromatin assembly factor-1 (CAF-1) chaperone regulates Cse4 deposition into chromatin in budding yeast Nucleic Acids Res., 2018-05-18;0(0):. 2018-05-18 [PMID: 29522205] (Bioassay, Human) |
Bioassay |
Human |
| Y Cho, HG Kang, SJ Kim, S Lee, S Jee, SG Ahn, MJ Kang, JS Song, JY Chung, EC Yi, KH Chun Post-translational modification of OCT4 in breast cancer tumorigenesis Cell Death Differ., 2018-03-06;0(0):. 2018-03-06 [PMID: 29511337] (Bioassay, Human) |
Bioassay |
Human |
| L Zheng, SD Conner PI5P4K? functions in DTX1-mediated Notch signaling Proc. Natl. Acad. Sci. U.S.A., 2018-02-12;0(0):. 2018-02-12 [PMID: 29440432] (Bioassay, Human) |
Bioassay |
Human |
| M Higa, K Tanaka, M Saijo Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7 FEBS J., 2018-01-25;0(0):. 2018-01-25 [PMID: 29323787] (Bioassay) |
Bioassay |
|
| X Chen, Z He, M Fu, Y Wang, H Wu, X Li, H Cao, SJ Zheng The E3 ubiquitin ligase Siah-1 suppresses avian reovirus infection by targeting p10 for degradation J. Virol., 2018-02-26;0(0):. 2018-02-26 [PMID: 29321312] (Bioassay) |
Bioassay |
|
| SY Kim, HJ Kim, HJ Kim, DH Kim, CH Kim, JH Han, HK Byeon, K Lee HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer Autophagy, 2018-02-21;0(0):1-89. 2018-02-21 [PMID: 29260979] (Bioassay, Human) |
Bioassay |
Human |
| JR Brickner, JM Soll, PM Lombardi, CB Vågbø, MC Mudge, C Oyeniran, R Rabe, J Jackson, ME Sullender, E Blazosky, AK Byrum, Y Zhao, MA Corbett, J Gécz, M Field, A Vindigni, G Slupphaug, C Wolberger, N Mosammapar A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair Nature, 2017-11-08;551(7680):389-393. 2017-11-08 [PMID: 29144457] (Bioassay, Human) |
Bioassay |
Human |
| Y Kopp, WH Lang, TB Schuster, A Martínez-L, HF Hofbauer, R Ernst, G Calloni, RM Vabulas CHIP as a membrane-shuttling proteostasis sensor Elife, 2017-11-01;6(0):. 2017-11-01 [PMID: 29091030] (Bioassay, Human) |
Bioassay |
Human |
| N Lian, X Liu, X Wang, Y Zhou, H Li, J Li, T Mao COP1 mediates dark-specific degradation of microtubule-associated protein WDL3 in regulating Arabidopsis hypocotyl elongation Proc. Natl. Acad. Sci. U.S.A., 2017-10-30;114(46):12321-12326. 2017-10-30 [PMID: 29087315] (Bioassay, Human) |
Bioassay |
Human |
| B Zhang, M Holmlund, S Lorrain, M Norberg, L Bakó, C Fankhauser, O Nilsson BLADE-ON-PETIOLE proteins act in an E3 ubiquitin ligase complex to regulate PHYTOCHROME INTERACTING FACTOR 4 abundance Elife, 2017-08-22;6(0):. 2017-08-22 [PMID: 28826468] (Bioassay, Human) |
Bioassay |
Human |
| H Janouskova, G El Tekle, E Bellini, ND Udeshi, A Rinaldi, A Ulbricht, T Bernasocch, G Civenni, M Losa, T Svinkina, CM Bielski, GV Kryukov, L Cascione, S Napoli, RI Enchev, DG Mutch, ME Carney, A Berchuck, BJN Winterhoff, RR Broaddus, P Schraml, H Moch, F Bertoni, CV Catapano, M Peter, SA Carr, LA Garraway, PJ Wild, JP Theurillat Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors Nat. Med., 2017-08-14;23(9):1046-1054. 2017-08-14 [PMID: 28805821] (Bioassay, Human) |
Bioassay |
Human |
| A Murali, J Shin, H Yurugi, A Krishnan, M Akutsu, A Carpy, B Macek, K Rajalingam Ubiquitin-dependent regulation of Cdc42 by XIAP Cell Death Dis, 2017-06-29;8(6):e2900. 2017-06-29 [PMID: 28661476] (Bioassay, Human) |
Bioassay |
Human |
| ZQ Fan, JY Chen, JF Kuang, WJ Lu, W Shan The Banana Fruit SINA Ubiquitin Ligase MaSINA1 Regulates the Stability of MaICE1 to be Negatively Involved in Cold Stress Response Front Plant Sci, 2017-06-12;8(0):995. 2017-06-12 [PMID: 28659946] (Bioassay) |
Bioassay |
|
| A Bononi, C Giorgi, S Patergnani, D Larson, K Verbruggen, M Tanji, L Pellegrini, V Signorato, F Olivetto, S Pastorino, M Nasu, A Napolitano, G Gaudino, P Morris, G Sakamoto, LK Ferris, A Danese, A Raimondi, C Tacchetti, S Kuchay, HI Pass, EB Affar, H Yang, P Pinton, M Carbone BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation Nature, 2017-06-14;546(7659):549-553. 2017-06-14 [PMID: 28614305] (Bioassay) |
Bioassay |
|
| S Inano, K Sato, Y Katsuki, W Kobayashi, H Tanaka, K Nakajima, S Nakada, H Miyoshi, K Knies, A Takaori-Ko, D Schindler, M Ishiai, H Kurumizaka, M Takata RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination Mol. Cell, 2017-06-01;66(5):622-634.e8. 2017-06-01 [PMID: 28575658] (Enzyme Assay, Human) |
Enzyme Assay |
Human |
| H Takeda, W Zhou, K Kido, R Suno, T Iwasaki, T Kobayashi, T Sawasaki CP5 system, for simple and highly efficient protein purification with a C-terminal designed mini tag PLoS ONE, 2017-05-25;12(5):e0178246. 2017-05-25 [PMID: 28542437] (Enzyme Assay) |
Enzyme Assay |
|
| V Glorian, J Allègre, J Berthelet, B Dumetier, PM Boutanquoi, N Droin, C Kayaci, J Cartier, S Gemble, G Marcion, D Gonzalez, R Boidot, C Garrido, O Michaud, E Solary, L Dubrez DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues Cell Death Dis, 2017-05-25;8(5):e2816. 2017-05-25 [PMID: 28542143] (Bioassay, Bacteria - E. Coli, Human) |
Bioassay |
Bacteria - E. Coli, Human |
| S Schunter, R Villa, V Flynn, JB Heidelberg, AK Classen, P Beli, PB Becker Ubiquitylation of the acetyltransferase MOF in Drosophila melanogaster PLoS ONE, 2017-05-16;12(5):e0177408. 2017-05-16 [PMID: 28510597] (Bioassay, Worm - Spodoptera frugiperda (Fall Army Worm)) |
Bioassay |
Worm - Spodoptera frugiperda (Fall Army Worm) |
| X Xu, PK Kathare, VN Pham, Q Bu, A Nguyen, E Huq Reciprocal proteasome-mediated degradation of PIFs and HFR1 underlying photomorphogenic development in Arabidopsis Development, 2017-04-18;0(0):. 2017-04-18 [PMID: 28420710] (Bioassay) |
Bioassay |
|
| C Perea-Resa, MA Rodríguez-, E Iniesto, V Rubio, J Salinas Prefoldins Negatively Regulate Cold Acclimation in Arabidopsis Thaliana By Promoting Nuclear Proteasome-Mediated HY5 Degradation Mol Plant, 2017-04-12;0(0):. 2017-04-12 [PMID: 28412546] (Bioassay) |
Bioassay |
|
| X Wei, X Wang, J Zhan, Y Chen, W Fang, L Zhang, H Zhang Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation J. Cell Biol., 2017-04-13;0(0):. 2017-04-13 [PMID: 28408404] (Bioassay) |
Bioassay |
|
| J Wang, H Yu, G Xiong, Z Lu, Y Jiao, X Meng, G Liu, X Chen, Y Wang, J Li Tissue-specific Ubiquitination by IPA1 INTERACTING PROTEIN 1 Modulates IPA1 Protein Levels to Regulate Plant Architecture in Rice Plant Cell, 2017-03-14;0(0):. 2017-03-14 [PMID: 28298520] (Bioassay) |
Bioassay |
|
| JH Kim, S Shin, J Seo, EW Lee, M Jeong, MS Lee, HJ Han, J Song C-terminus of HSC70-Interacting Protein (CHIP) Inhibits Adipocyte Differentiation via Ubiquitin- and Proteasome-Mediated Degradation of PPAR? Sci Rep, 2017-01-06;7(0):40023. 2017-01-06 [PMID: 28059128] (Ubiquitination, Human, Mouse) |
Ubiquitination |
Human, Mouse |
| Xueting Lang TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity J. Exp. Med, 2016-12-28;0(0):. 2016-12-28 [PMID: 28031478] (Bioassay, Human) |
Bioassay |
Human |
| Andrea Braganza UBE3B is a Calmodulin-Regulated, Mitochondria-Associated E3 Ubiquitin Ligase J. Biol. Chem, 2016-12-21;0(0):. 2016-12-21 [PMID: 28003368] (Bioassay, Human) |
Bioassay |
Human |
| Ekta Tripathi Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution EMBO J, 2016-12-19;0(0):. 2016-12-19 [PMID: 27993934] (Bioassay) |
Bioassay |
|
| Francesca Nazio Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation J. Cell Biol, 2016-12-08;215(6):841-856. 2016-12-08 [PMID: 27932573] (Bioassay, Human) |
Bioassay |
Human |
| Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity Nucleic Acids Res., 2017-02-28;0(0):. 2017-02-28 [PMID: 27903893] (Bioassay) |
Bioassay |
|
| SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer Oncogene, 2016-11-21;0(0):. 2016-11-21 [PMID: 27869166] (Bioassay) |
Bioassay |
|
| The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53 PLoS Biol., 2016-11-16;14(11):e2000733. 2016-11-16 [PMID: 27851749] (Bioassay) |
Bioassay |
|
| Lin Mei Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation Neuron, 2016-11-10;92(5):1007-1019. 2016-11-10 [PMID: 27839998] (Bioassay, Human) |
Bioassay |
Human |
| Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress Sci Rep, 2016-11-04;6(0):36171. 2016-11-04 [PMID: 27811966] (Bioassay, Human) |
Bioassay |
Human |
| RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes Elife, 2016-10-05;5(0):. 2016-10-05 [PMID: 27705745] (Bioassay) |
Bioassay |
|
| Identification and Characterization of MCM3 as a Novel KEAP1 Substrate J Biol Chem, 2016-09-12;0(0):. 2016-09-12 [PMID: 27621311] (Ubiquitination, Human) |
Ubiquitination |
Human |
| The San1 ubiquitin ligase functions preferentially with ubiquitin-conjugating enzyme Ubc1 during protein quality control J Biol Chem, 2016-07-12;0(0):. 2016-07-12 [PMID: 27405755] (Bioassay) |
Bioassay |
|
| Mary E Matyskiela A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase Nature, 2016-06-22;0(0):. 2016-06-22 [PMID: 27338790] (Bioassay) |
Bioassay |
|
| Kumarkrishna Raychaudhu 14-3-3? loss leads to activation of the epithelial to mesenchymal transition due to the stabilization of c-Jun J Biol Chem, 2016-06-03;0(0):. 2016-06-03 [PMID: 27261462] (Bioassay) |
Bioassay |
|
| LA Link, BV Howley, GS Hussey, PH Howe hnRNP E1 Protects Chromosomal Integrity by Translational Regulation of Cdc27 Mol Cancer Res, 2016-04-21;0(0):. 2016-04-21 [PMID: 27102006] (Bioassay, Mouse) |
Bioassay |
Mouse |
| J Qiu, MJ Sheedlo, K Yu, Y Tan, ES Nakayasu, C Das, X Liu, ZQ Luo Ubiquitination independent of E1 and E2 enzymes by bacterial effectors Nature, 2016-04-06;533(7601):120-4. 2016-04-06 [PMID: 27049943] (Bioassay, Human) |
Bioassay |
Human |
| H Zhang, H Liu, Y Chen, X Yang, P Wang, T Liu, M Deng, B Qin, C Correia, S Lee, J Kim, M Sparks, AA Nair, DL Evans, KR Kalari, P Zhang, L Wang, Z You, SH Kaufmann, Z Lou, H Pei A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice Nat Commun, 2016-01-05;7(0):10201. 2016-01-05 [PMID: 26727879] (Bioassay, Human) |
Bioassay |
Human |
| Kim C, Yun N, Lee J, Youdim M, Ju C, Kim W, Han P, Oh Y Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death. Cell Death Differ, 2015-07-24;23(2):333-46. 2015-07-24 [PMID: 26206088] (Enzyme Assay) |
Enzyme Assay |
|
| Hsiao H, Hsu T, Liu W, Hsieh W, Chou T, Wu Y, Jiang S, Lai M Deltex1 antagonizes HIF-1alpha and sustains the stability of regulatory T cells in vivo. Nat Commun, 2015-02-19;6(0):6353. 2015-02-19 [PMID: 25695215] (Bioassay) |
Bioassay |
|
| Xue J, Chen Y, Wu Y, Wang Z, Zhou A, Zhang S, Lin K, Aldape K, Majumder S, Lu Z, Huang S Tumour suppressor TRIM33 targets nuclear beta-catenin degradation. Nat Commun, 2015-02-02;6(0):6156. 2015-02-02 [PMID: 25639486] (Bioassay, Human) |
Bioassay |
Human |
| Rout , Manoj K, Hodge , Curtis D, Markin , Craig J, Xu , Xin, Glover , J N Mark, Xiao , Wei, Spyracopoulos , Leo Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes. J Am Chem Soc, 2014-12-05;136(50):17446-58. 2014-12-05 [PMID: 25423605] (Bioassay) |
Bioassay |
|
| Yue , Shen, Tang , Liu-Ya, Tang , Ying, Tang , Yi, Shen , Qiu-Hong, Ding , Jie, Chen , Yan, Zhang , Zengdi, Yu , Ting-Tin, Zhang , Ying E, Cheng , Steven Y Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception. Elife, 2014-06-12;3(0):. 2014-06-12 [PMID: 24925320] (Bioassay) |
Bioassay |
|
| Kumar , Ravindra, Whitehurst , Christop, Pagano , Joseph S The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity. J Virol, 2014-03-26;88(11):6411-22. 2014-03-26 [PMID: 24672041] (Bioassay, N/A) |
Bioassay |
N/A |
| Townley-Tilson , W H Davi, Wu , Yaxu, Ferguson , James E, Patterson , Cam The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2. PLoS ONE, 2014-02-21;9(2):e89451. 2014-02-21 [PMID: 24586788] (Ubiquitination, Human) |
Ubiquitination |
Human |
| Lonskaya I, Desforges N, Hebron M, Moussa C Ubiquitination increases parkin activity to promote autophagic alpha-synuclein clearance. PLoS ONE, 2013-12-26;8(12):e83914. 2013-12-26 [PMID: 24386307] (Enzyme Assay) |
Enzyme Assay |
|
| Hornburger M, Mayer B, Leonhardt S, Willer E, Zahler S, Beyerle A, Rajalingam K, Vollmar A, Furst R A novel role for inhibitor of apoptosis (IAP) proteins as regulators of endothelial barrier function by mediating RhoA activation. FASEB J, 2013-12-26;28(4):1938-46. 2013-12-26 [PMID: 24371121] (Ubiquitination, Human) |
Ubiquitination |
Human |
| Liu , Weixiao, Shang , Yonglian, Zeng , Yan, Liu , Chao, Li , Yanchang, Zhai , Linhui, Wang , Pan, Lou , Jizhong, Xu , Ping, Ye , Yihong, Li , Wei Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains. EMBO J, 2013-12-23;33(1):46-61. 2013-12-23 [PMID: 24366945] (Bioassay) |
Bioassay |
|
| Kim J, Park K, Lee E, Jang W, Seo J, Shin S, Hwang K, Song J Suppression of PPARgamma through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation. Cell Death Differ, 2013-12-13;21(4):594-603. 2013-12-13 [PMID: 24336050] (Enzyme Assay, Human) |
Enzyme Assay |
Human |
| Lee , Hyojin, Alpi , Arno F, Park , Mi So, Rose , Ann, Koo , Hyeon-So C. elegans ring finger protein RNF-113 is involved in interstrand DNA crosslink repair and interacts with a RAD51C homolog. PLoS ONE, 2013-03-28;8(3):e60071. 2013-03-28 [PMID: 23555887] (Enzyme Assay, Human) |
Enzyme Assay |
Human |
| Rajbhandari P, Schalper K, Solodin N, Ellison-Zelski S, Ping Lu K, Rimm D, Alarid E Pin1 modulates ERalpha levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation. Oncogene, 2013-04-01;33(11):1438-47. 2013-04-01 [PMID: 23542176] (Bioassay) |
Bioassay |
|
| Singer , Alexande, Schulze , Sebastia, Skarina , Tatiana, Xu , Xiaohui, Cui , Hong, Eschen-Lippold , Lennart, Egler , Monique, Srikumar , Tharan, Raught , Brian, Lee , Justin, Scheel , Dierk, Savchenko , Alexei, Bonas , Ulla A pathogen type III effector with a novel E3 ubiquitin ligase architecture. PLoS Pathog, 2013-01-24;9(1):e1003121. 2013-01-24 [PMID: 23359647] (Bioassay) |
Bioassay |
|
| Stanley D, Bartholomeeusen K, Crosby D, Kim D, Kwon E, Yen L, Cartozo N, Li M, Jager S, Mason-Herr J, Hayashi F, Yokoyama S, Krogan N, Harris R, Peterlin B, Gross J Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G. PLoS Pathog, 2012-12-27;8(12):e1003085. 2012-12-27 [PMID: 23300442] (Bioassay) |
Bioassay |
|
| Bosch D, Siderovski D Structural determinants of ubiquitin conjugation in Entamoeba histolytica. J Biol Chem, 2012-12-03;288(4):2290-302. 2012-12-03 [PMID: 23209297] (Bioassay, Amoeba - Entamoeba histolytica) |
Bioassay |
Amoeba - Entamoeba histolytica |
| Lee , T-H, Park , J-M, Leem , S-H, Kang , T-H Coordinated regulation of XPA stability by ATR and HERC2 during nucleotide excision repair. Oncogene, 2012-11-26;33(1):19-25. 2012-11-26 [PMID: 23178497] (Bioassay) |
Bioassay |
|
| Wang , Jingya, Muntean , Andrew G, Wu , Laura, Hess , Jay L A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity. J Biol Chem, 2012-11-05;287(52):43410-6. 2012-11-05 [PMID: 23129768] (Ubiquitination, Human) |
Ubiquitination |
Human |
| Varfolomeev , Eugene, Moradi , Elham, Dynek , Jasmin N, Zha , Jiping, Fedorova , Anna V, Deshayes , Kurt, Fairbrother , Wayne J, Newton , Kim, Le Couter , Jennifer, Vucic , Domagoj Characterization of ML-IAP protein stability and physiological role in vivo. Biochem J, 2012-11-01;447(3):427-36. 2012-11-01 [PMID: 22853455] (Bioassay, Human) |
Bioassay |
Human |
| Pelisch F, Pozzi B, Risso G, Munoz M, Srebrow A DNA damage-induced heterogeneous nuclear ribonucleoprotein K sumoylation regulates p53 transcriptional activation. J Biol Chem, 2012-07-23;287(36):30789-99. 2012-07-23 [PMID: 22825850] (Bioassay) |
Bioassay |
|
| Bell JL, Malyukova A, Holien JK TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members. PLoS ONE, 2012-05-21;7(5):e37470. 2012-05-21 [PMID: 22629402] (Bioassay, Human) |
Bioassay |
Human |
|
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