Name: Recombinant Human UbcH5a/UBE2D1 Protein, CF
Brand: Novus Biologicals
SKU: E2-616
Price: 322 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	Enzyme Activity
Format	Carrier-Free

Details of Functionality	Recombinant Human UbcH5a/UBE2D1 is a member of the Ubiquitin-conjugating (E2) enzyme family that receives Ubiquitin from a Ubiquitin-activating (E1) enzyme and subsequently interacts with a Ubiquitin ligase (E3) to conjugate Ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human UbcH5a/UBE2D1 concentration of 0.1-1 μM.
Source	E. coli-derived human UbcH5a/UBE2D1 protein Met1 - Met147
Accession #	P51668.1
Protein/Peptide Type	Recombinant Enzymes
Gene	UBE2D1
Purity	>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.
Buffer	Supplied as a solution in HEPES, NaCl, TCEP and Glycerol.
Purity	>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.

Publications using E2-616	Applications	Species
Lu, J;Yu, J;Liu, P;Gu, J;Chen, Y;Zhang, T;Li, J;Wang, T;Yang, W;Lin, R;Wang, F;Qi, M;Li, T;Liu, Y; Ubiquitin-mediated degradation of SlPsbS regulates low night temperature tolerance in tomatoes Cell reports 2024-09-19 [PMID: 39302836] (Bioassay, E. coli)	Bioassay	E. coli
Wang, S;Li, H;Liu, X;Yin, T;Li, T;Zheng, M;Liu, M;Meng, X;Zhou, J;Wang, Y;Chen, Y; VHL suppresses UBE3B-mediated breast tumor growth and metastasis Cell death & disease 2024-06-24 [PMID: 38914543] (Bioassay, N/A)	Bioassay	N/A
Radko-Juettner, S;Yue, H;Myers, JA;Carter, RD;Robertson, AN;Mittal, P;Zhu, Z;Hansen, BS;Donovan, KA;Hunkeler, M;Rosikiewicz, W;Wu, Z;McReynolds, MG;Roy Burman, SS;Schmoker, AM;Mageed, N;Brown, SA;Mobley, RJ;Partridge, JF;Stewart, EA;Pruett-Miller, SM;Nabet, B;Peng, J;Gray, NS;Fischer, ES;Roberts, CWM; Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF Nature 2024-03-27 [PMID: 38538798] (Bioassay, N/A)	Bioassay	N/A
Zhu, K;Suskiewicz, MJ;Chatrin, C;Strømland, Ø;Dorsey, BW;Aucagne, V;Ahel, D;Ahel, I; DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids Nucleic acids research 2023-11-24 [PMID: 38000390] (Bioassay, N/A)	Bioassay	N/A
Li, P;Zhen, Y;Kim, C;Liu, Z;Hao, J;Deng, H;Deng, H;Zhou, M;Wang, XD;Qin, T;Yu, Y; Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer Science advances 2023-10-27 [PMID: 37878693] (Bioassay, Human)	Bioassay	Human
Singh, S;Yeat, NY;Wang, YT;Lin, SY;Kuo, IY;Wu, KP;Wang, WJ;Wang, WC;Su, WC;Wang, YC;Chen, RH; PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target Cell death & disease 2023-10-11 [PMID: 37821451] (Bioassay, N/A)	Bioassay	N/A
Dobish, KK;Wittorf, KJ;Swenson, SA;Bean, DC;Gavile, CM;Woods, NT;Ghosal, G;Hyde, RK;Buckley, SM; FBXO21 mediated degradation of p85? regulates proliferation and survival of acute myeloid leukemia Leukemia 2023-09-09 [PMID: 37689825] (Ubiquitination, Human)	Ubiquitination	Human
Meyers, M;Cismoski, S;Panidapu, A;Chie-Leon, B;Nomura, DK; Targeted Protein Degradation through Recruitment of the CUL4A Complex Adaptor Protein DDB1 bioRxiv : the preprint server for biology 2023-08-12 [PMID: 37614621] (Bioassay, N/A)	Bioassay	N/A
L Kong, C Sui, T Chen, L Zhang, W Zhao, Y Zheng, B Liu, X Cheng, C Gao The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus Cell Reports, 2023-03-26;42(4):112306. 2023-03-26 [PMID: 36972172] (Ubiquitination, Human)	Ubiquitination	Human
A Belmonte-F, J Herrero-Ru, M Galindo-Mo, MC Limón-Mort, M Mora-Santo, C Sáez, MÁ Japón, M Tortolero, F Romero Cisplatin-induced cell death increases the degradation of the MRE11-RAD50-NBS1 complex through the autophagy/lysosomal pathway Cell Death and Differentiation, 2022-12-08;0(0):. 2022-12-08 [PMID: 36477079] (Bioassay, Human)	Bioassay	Human
A Belmonte-F, J Herrero-Ru, M Galindo-Mo, MC Limón-Mort, M Mora-Santo, C Sáez, MÁ Japón, M Tortolero, F Romero Cisplatin-induced cell death increases the degradation of the MRE11-RAD50-NBS1 complex through the autophagy/lysosomal pathway Cell Death and Differentiation, 2022;0(0):. 2022 [PMID: 36477079] (Bioassay, Human)	Bioassay	Human
K Zhu, MJ Suskiewicz, A Hloušek-Ka, H Meudal, A Miko?, V Aucagne, D Ahel, I Ahel DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates Science Advances, 2022-10-05;8(40):eadd4253. 2022-10-05 [PMID: 36197986] (Bioassay, Human)	Bioassay	Human
H Zhuang, Y Ren, C Mao, Y Zhong, Z Zhang, B Cao, Y Zhang, J Huang, G Xu, Z Huang, Y Xu, X Mao Induction of zinc finger protein RNF6 auto-ubiquitination for the treatment of myeloma and chronic myeloid leukemia The Journal of Biological Chemistry, 2022-08-01;298(9):102314. 2022-08-01 [PMID: 35926709] (Bioassay, N/A)	Bioassay	N/A
K Ghilarducc, VC Cabana, A Harake, L Cappadocia, MP Lussier Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167 International Journal of Molecular Sciences, 2022-07-16;23(14):. 2022-07-16 [PMID: 35887194] (Bioassay, Human)	Bioassay	Human
X Ma, X Ma, L Zhu, Y Zhao, M Chen, T Li, Y Lin, D Ma, C Sun, L Han The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling Oncogenesis, 2022-07-20;11(1):40. 2022-07-20 [PMID: 35858925] (Bioassay, Human)	Bioassay	Human
D Deshmukh, J Xu, X Yang, H Shimelis, S Fang, Y Qiu Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6 Pharmaceutics, 2022-04-06;14(4):. 2022-04-06 [PMID: 35456636] (Bioassay, N/A)	Bioassay	N/A
S Kaisari, S Miniowitz-, D Sitry-Shev, P Shomer, G Kozlov, K Gehring, A Hershko Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes Proceedings of the National Academy of Sciences of the United States of America, 2022-03-01;119(9):. 2022-03-01 [PMID: 35217622] (Bioassay, Human)	Bioassay	Human
M Won, KA Park, S Kim, E Ju, Y Ko, H Yoo, H Ro, J Lee, J Oh, EG Lee, SY Kim, SW Nam, HM Shen, MK Yeo, JM Kim, GM Hur ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-kappaB Cell Death and Differentiation, 2021-11-27;0(0):. 2021-11-27 [PMID: 34839354] (Bioassay, Human)	Bioassay	Human
RK Manne, Y Agrawal, SK Malonia, S Banday, S Edachery, A Patel, A Kumar, P Shetty, MK Santra FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX The Journal of Biological Chemistry, 2021-09-26;0(0):101253. 2021-09-26 [PMID: 34587475] (Bioassay, Human)	Bioassay	Human
C Shen, A Nayak, LR Neitzel, AA Adams, M Silver-Ise, LM Sawyer, H Benchabane, H Wang, N Bunnag, B Li, DT Wynn, F Yang, M Garcia-Con, CH Williams, S Dakshanamu, CC Hong, NG Ayad, AJ Capobianco, Y Ahmed, E Lee, DJ Robbins The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling Nature Communications, 2021-09-06;12(1):5263. 2021-09-06 [PMID: 34489457] (Bioassay, Human)	Bioassay	Human
Y Sun, J Chen, SN Huang, YP Su, W Wang, K Agama, S Saha, LM Jenkins, JM Pascal, Y Pommier PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation Nature Communications, 2021-08-18;12(1):5010. 2021-08-18 [PMID: 34408146] (Bioassay)	Bioassay
S Shukla, W Ying, F Gray, Y Yao, ML Simes, Q Zhao, H Miao, HJ Cho, P González-A, A Winkler, G Lund, T Purohit, E Kim, X Zhang, JM Ray, S He, C Nikolaidis, J Ndoj, J Wang, ? Jaremko, M Jaremko, RJH Ryan, ML Guzman, J Grembecka, T Cierpicki Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain Nature Chemical Biology, 2021-06-21;17(7):784-793. 2021-06-21 [PMID: 34155404] (Ubiquitination, Human)	Ubiquitination	Human
P Zhang, Z Zhang, Y Fu, Y Zhang, MP Washburn, L Florens, M Wu, C Huang, Z Hou, M Mohan K63-linked ubiquitination of DYRK1A by TRAF2 alleviates Sprouty 2-mediated degradation of EGFR Cell Death & Disease, 2021-06-11;12(6):608. 2021-06-11 [PMID: 34117217] (Bioassay, Human)	Bioassay	Human
OM Khan, J Almagro, JK Nelson, S Horswell, V Encheva, KS Keyan, BE Clurman, AP Snijders, A Behrens Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12 Nature Communications, 2021-04-06;12(1):2043. 2021-04-06 [PMID: 33824312] (Bioassay, Human)	Bioassay	Human
JK Barrows, G Fullbright, DT Long BRCA1-BARD1 regulates transcription through BRD4 in Xenopus nucleoplasmic extract Nucleic Acids Research, 2021-04-06;0(0):. 2021-04-06 [PMID: 33660782] (Ubiquitination, N/A)	Ubiquitination	N/A
MC Albert, K Brinkmann, W Pokrzywa, SD Günther, M Krönke, T Hoppe, H Kashkar CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage Cell Death & Disease, 2020-09-10;11(9):740. 2020-09-10 [PMID: 32913203] (Ubiquitylation, Human)	Ubiquitylation	Human
CR Kim, T Noda, H Kim, G Kim, S Park, Y Na, S Oura, K Shimada, I Bang, JY Ahn, YR Kim, SK Oh, HJ Choi, JS Kim, I Jung, H Lee, Y Okada, M Ikawa, SH Baek PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis Cell Rep, 2020-07-28;32(4):107950. 2020-07-28 [PMID: 32726616] (Bioassay, Mouse)	Bioassay	Mouse
M S?abicki, Z Kozicka, G Petzold, YD Li, M Manojkumar, RD Bunker, KA Donovan, QL Sievers, J Koeppel, D Suchyta, AS Sperling, EC Fink, JA Gasser, LR Wang, SM Corsello, RS Sellar, M Jan, D Gillingham, C Scholl, S Fröhling, TR Golub, ES Fischer, NH Thomä, BL Ebert The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K Nature, 2020-06-03;0(0):. 2020-06-03 [PMID: 32494016] (Bioassay, N/A)	Bioassay	N/A
ME Matyskiela, T Clayton, X Zheng, C Mayne, E Tran, A Carpenter, B Pagarigan, J McDonald, M Rolfe, LG Hamann, G Lu, PP Chamberlai Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex Nat. Struct. Mol. Biol., 2020-04-06;27(4):319-322. 2020-04-06 [PMID: 32251415] (Ubiquitination, Spodoptera frugiperda)	Ubiquitination	Spodoptera frugiperda
X Li, M Guo, L Cai, T Du, Y Liu, HF Ding, H Wang, J Zhang, X Chen, C Yan Competitive ubiquitination activates the tumor suppressor p53 Cell Death Differ., 2019-12-02;0(0):. 2019-12-02 [PMID: 31796886] (Bioassay, Human)	Bioassay	Human
TC Ting, M Goralski, K Klein, B Wang, J Kim, Y Xie, D Nijhawan Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15 Cell Rep, 2019-11-05;29(6):1499-1510.e6. 2019-11-05 [PMID: 31693891] (Bioassay, Human)	Bioassay	Human
J Sitz, SA Blanchet, SF Gameiro, E Biquand, TM Morgan, M Galloy, J Dessapt, EG Lavoie, A Blondeau, BC Smith, JS Mymryk, CA Moody, A Fradet-Tur Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response Proc. Natl. Acad. Sci. U.S.A., 2019-09-09;116(39):19552-19562. 2019-09-09 [PMID: 31501315] (Bioassay, Virus - HPV)	Bioassay	Virus - HPV
MCJ Yip, AFA Keszei, Q Feng, V Chu, MJ McKenna, S Shao Mechanism for recycling tRNAs on stalled ribosomes Nat. Struct. Mol. Biol., 2019-04-22;0(0):. 2019-04-22 [PMID: 31011209] (Ubiquitination, Human)	Ubiquitination	Human
G Lu, J Yi, A Gubas, YT Wang, Y Wu, Y Ren, M Wu, Y Shi, C Ouyang, HWS Tan, T Wang, L Wang, ND Yang, S Deng, D Xia, RH Chen, SA Tooze, HM Shen Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation Autophagy, 2019-03-30;0(0):1-18. 2019-03-30 [PMID: 30898011] (Bioassay)	Bioassay
OE Akande, PK Damle, M Pop, NE Sherman, BB Szomju, LV Litovchick, SR Grossman DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination Cell Rep, 2019-03-19;26(12):3323-3335.e4. 2019-03-19 [PMID: 30893604] (Bioassay)	Bioassay
Y Dong, S Zhang, Z Wu, X Li, WL Wang, Y Zhu, S Stoilova-M, Y Lu, D Finley, Y Mao Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome Nature, 2018-11-12;0(0):. 2018-11-12 [PMID: 30479383] (Bioassay, Human)	Bioassay	Human
ME Matyskiela, S Couto, X Zheng, G Lu, J Hui, K Stamp, C Drew, Y Ren, M Wang, A Carpenter, CW Lee, T Clayton, W Fang, CC Lu, M Riley, P Abdubek, K Blease, J Hartke, G Kumar, R Vessey, M Rolfe, LG Hamann, PP Chamberlai SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate Nat. Chem. Biol., 2018-09-06;0(0):. 2018-09-06 [PMID: 30190590] (Ubiquitination, Human)	Ubiquitination	Human
P Amin, M Florez, A Najafov, H Pan, J Geng, D Ofengeim, SA Dziedzic, H Wang, VJ Barrett, Y Ito, MJ LaVoie, J Yuan Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNF?-mediated apoptosis Proc. Natl. Acad. Sci. U.S.A., 2018-06-11;115(26):E5944-E5953. 2018-06-11 [PMID: 29891719] (Bioassay)	Bioassay
S Ito, A Ueno, T Ueda, H Nakagawa, H Taniguchi, N Kayukawa, A Fujihara-I, F Hongo, K Okihara, O Ukimura CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells Oncotarget, 2018-04-03;9(25):17645-17655. 2018-04-03 [PMID: 29707137] (Bioassay)	Bioassay
R Khanna, V Krishnamoo, VK Parnaik E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins FEBS J., 2018-05-03;0(0):. 2018-05-03 [PMID: 29676528] (Bioassay, Human)	Bioassay	Human
M Ratliff, KL Hill-Harfe, EJ Gleason, H Ling, TL Kroft, SW L'Hernault MIB-1 Is Required for Spermatogenesis and Facilitates LIN-12 and GLP-1 Activity inCaenorhabditis elegans Genetics, 2018-03-12;0(0):. 2018-03-12 [PMID: 29531012] (Bioassay)	Bioassay
L Zheng, SD Conner PI5P4K? functions in DTX1-mediated Notch signaling Proc. Natl. Acad. Sci. U.S.A., 2018-02-12;0(0):. 2018-02-12 [PMID: 29440432] (Bioassay, Human)	Bioassay	Human
A Murali, J Shin, H Yurugi, A Krishnan, M Akutsu, A Carpy, B Macek, K Rajalingam Ubiquitin-dependent regulation of Cdc42 by XIAP Cell Death Dis, 2017-06-29;8(6):e2900. 2017-06-29 [PMID: 28661476] (Bioassay, Human)	Bioassay	Human
V Glorian, J Allègre, J Berthelet, B Dumetier, PM Boutanquoi, N Droin, C Kayaci, J Cartier, S Gemble, G Marcion, D Gonzalez, R Boidot, C Garrido, O Michaud, E Solary, L Dubrez DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues Cell Death Dis, 2017-05-25;8(5):e2816. 2017-05-25 [PMID: 28542143] (Bioassay, Bacteria - E. Coli, Human)	Bioassay	Bacteria - E. Coli, Human
J An, CM Ponthier, R Sack, J Seebacher, MB Stadler, KA Donovan, ES Fischer pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4(CRBN) ubiquitin ligase Nat Commun, 2017-05-22;8(0):15398. 2017-05-22 [PMID: 28530236] (Bioassay)	Bioassay
CS Yang, K Jividen, A Spencer, N Dworak, L Ni, LT Oostdyk, M Chatterjee, B Ku?mider, B Reon, M Parlak, V Gorbunova, T Abbas, E Jeffery, NE Sherman, BM Paschal Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9 Mol. Cell, 2017-05-18;66(4):503-516.e5. 2017-05-18 [PMID: 28525742] (Bioassay, Human)	Bioassay	Human
Y Lee, TF Chou, SK Pittman, AL Keith, B Razani, CC Weihl Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination Cell Rep, 2017-04-04;19(1):188-202. 2017-04-04 [PMID: 28380357] (Bioassay, Mouse)	Bioassay	Mouse
K Kliza, C Taumer, I Pinzuti, M Franz-Wach, S Kunzelmann, B Stieglitz, B Macek, K Husnjak Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry Nat. Methods, 2017-03-20;0(0):. 2017-03-20 [PMID: 28319114] (Bioassay)	Bioassay
T Nakamura, K Murakami, H Tada, Y Uehara, J Nogami, K Maehara, Y Ohkawa, H Saitoh, H Nishitani, T Ono, R Nishi, M Yokoi, W Sakai, K Sugasawa Thymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms Genes Cells, 2017-03-20;0(0):. 2017-03-20 [PMID: 28318075] (Bioassay)	Bioassay
Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity Nucleic Acids Res., 2017-02-28;0(0):. 2017-02-28 [PMID: 27903893] (Bioassay)	Bioassay
Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal Nat Commun, 2016-07-28;7(0):12326. 2016-07-28 [PMID: 27465491] (Bioassay)	Bioassay
Mary E Matyskiela A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase Nature, 2016-06-22;0(0):. 2016-06-22 [PMID: 27338790] (Bioassay)	Bioassay
The adenovirus E4-ORF3 protein functions as a SUMO E3 ligase for TIF-1? sumoylation and poly-SUMO chain elongation Proc Natl Acad Sci USA, 2016-05-31;113(24):6725-30. 2016-05-31 [PMID: 27247387] (Bioassay, Human)	Bioassay	Human
Sanchez C, Liu C, Mayer S, Nurhasanah A, Cyrklaff M, Mu J, Ferdig M, Stein W, Lanzer M A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. PLoS Genet, 2014-05-15;10(5):e1004382. 2014-05-15 [PMID: 24830312] (Bioassay, Parasite - Plasmodium falciparum)	Bioassay	Parasite - Plasmodium falciparum
Guicciardi , Maria Eu, Werneburg , Nathan W, Bronk , Steven F, Franke , Adrian, Yagita , Hideo, Thomas , Gary, Gores , Gregory Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. PLoS ONE, 2014-03-14;9(3):e92124. 2014-03-14 [PMID: 24633224] (Bioassay)	Bioassay
Townley-Tilson , W H Davi, Wu , Yaxu, Ferguson , James E, Patterson , Cam The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2. PLoS ONE, 2014-02-21;9(2):e89451. 2014-02-21 [PMID: 24586788] (Ubiquitination, Human)	Ubiquitination	Human
Hornburger M, Mayer B, Leonhardt S, Willer E, Zahler S, Beyerle A, Rajalingam K, Vollmar A, Furst R A novel role for inhibitor of apoptosis (IAP) proteins as regulators of endothelial barrier function by mediating RhoA activation. FASEB J, 2013-12-26;28(4):1938-46. 2013-12-26 [PMID: 24371121] (Ubiquitination, Human)	Ubiquitination	Human
Lee , Hyojin, Alpi , Arno F, Park , Mi So, Rose , Ann, Koo , Hyeon-So C. elegans ring finger protein RNF-113 is involved in interstrand DNA crosslink repair and interacts with a RAD51C homolog. PLoS ONE, 2013-03-28;8(3):e60071. 2013-03-28 [PMID: 23555887] (Enzyme Assay, Human)	Enzyme Assay	Human
Rajbhandari P, Schalper K, Solodin N, Ellison-Zelski S, Ping Lu K, Rimm D, Alarid E Pin1 modulates ERalpha levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation. Oncogene, 2013-04-01;33(11):1438-47. 2013-04-01 [PMID: 23542176] (Bioassay)	Bioassay
Varfolomeev , Eugene, Moradi , Elham, Dynek , Jasmin N, Zha , Jiping, Fedorova , Anna V, Deshayes , Kurt, Fairbrother , Wayne J, Newton , Kim, Le Couter , Jennifer, Vucic , Domagoj Characterization of ML-IAP protein stability and physiological role in vivo. Biochem J, 2012-11-01;447(3):427-36. 2012-11-01 [PMID: 22853455] (Bioassay, Human)	Bioassay	Human
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Recombinant Human UbcH5a/UBE2D1 Protein, CF

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Gene Symbol	UBE2D1
Uniprot	P51668.1()