Species: Hu, Mu, Rt, Bv, Ch, RM, Xp
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: Enzyme Activity
Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
7321 |
| Alternate Names |
- E2(17)KB1
- Stimulator of Fe transportUBC4/5 homolog
- UBC4/5
- UBC5A
- UbcH5
- UbcH5A
- UBCH5AEC 6.3.2.19
- UBCH5SFT
- Ubiquitin carrier protein D1
- ubiquitin-conjugating enzyme E2 D1
- Ubiquitin-conjugating enzyme E2(17)KB 1
- Ubiquitin-conjugating enzyme E2-17 kDa 1
- ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)
- Ubiquitin-protein ligase D1
|
Research Areas for UbcH5a/UBE2D1
Find related products by research area and learn more about each of the different research areas below.
CancerHypoxia
