Recombinant Human TRAIL R2 Fc Alexa Fluor® 488 Protein

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This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human TRAIL R2, also called DR5 and TRICK 2 is a type 1, TNF R family, membrane protein which is a receptor for TRAIL (APO2 ligand) (1). In the new TNF superfamily nomenclature, TRAIL R2 is referred to as TNFRSF10B. TRAIL R2 cDNA encodes a 440 amino acid residue precursor protein containing extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. Among TNF receptor family proteins, TRAIL R2 is most closely related to TRAIL R1/DR4, sharing 55% amino acid sequence identity. There are no known rat or mouse homologs to TRAILR2. Binding of trimeric TRAIL to TRAIL R2 induces apoptosis (1, 2). The induction of apoptosis likely requires oligomerization of the receptor. The human TRAIL R2/Fc chimera neutralizes the ability of TRAIL to induce apoptosis (1, 2). Besides TRAIL R2, an additional TRAIL R1/DR4, which tranduces apoptosis signaling, and two TRAIL decoy receptors, which antagonize TRAIL‑induced apoptosis, have been reported (3).

Array AFG10140

• TRAILR2/TNFRSF10B Antibodies
• TRAILR2/TNFRSF10B ELISA Kit
• TRAILR2/TNFRSF10B Lysates
• TRAILR2/TNFRSF10B Proteins
• TRAILR2/TNFRSF10B Proteins and Enzymes