Recombinant Human mGluR5 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Metabotropic glutamate receptors (mGluRs) are coupled to effector systems through GTP-binding proteins and modulate glutamate neurotransmission in the central and peripheral nervous systems (1). Structurally, members from this family are characterized by a large N-terminal extracellular domain (ECD), seven transmembrane, and a cytoplasmic carboxyl-terminal domain variable in length. Two ECDs dimerize together and large conformational changes are induced when agonists bind to one or both domains (3). Intracellularly, a short C-terminus interacts directly with a G-protein (2). The receptors are subdivided into three groups (I-III) based on sequence homology, signal transduction and pharmacological properties (1). Group I includes mGluR1 and mGluR5. This group has been shown to activate phospholipase C and regulates neuronal ion channel activity. Human mGluR5 is 1212 amino acids (aa) in length. The 2-509 amino acids domain represents the ECD, with the apparent molecular mass approximately 64 kDa in SDS-PAGE under reducing conditions. Through its ECD, mGluR5 either homodimerizes or heterodimerizes with the Ca⁺⁺ sensor receptor (4). Over aa 2-509, human mGluR5 is 98% aa identical to mouse and rat mGluR5.

Array 9529-UR

• mGluR5 Antibodies
• mGluR5 Proteins and Enzyme