Recombinant Human DSCAM-L1 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Down syndrome cell adhesion molecule-like protein 1 (DSCAM-L1; also DSCAM2) is a 224 kDa type I transmembrane glycoprotein and member of the immunoglobulin superfamily (1). Human DSCAM-L1 is a DSCAM paralog located on chromosome 11q23. It is synthesized as a 2053 amino acid (aa) precursor that contains an 18 aa signal sequence, a 1573 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 441 aa cytoplasmic tail. The ECD contains ten Ig-like C2-type domains, six fibronectin type-III domains, and 18 potential sites for N-linked glycosylation. A deletion of aa 34 ‑ 244 produces a second isoform. When compared to DSCAM, DSCAM-L1 shows 64% aa identity to the ECD and 45% aa identity to the cytoplasmic domain (1).  Human DSCAM-L1 is 95% aa identical to mouse DSCAM-L1. In the mouse brain, DSCAM-L1 is predominantly expressed in Purkinje cells of the cerebellum, granule cells of the dentate gyrus, and in neurons of the cerebral cortex and olfactory bulb (1). DSCAM-L1 exhibits homophilic binding activity that does not require divalent cations (1). Based on its similarities to DSCAM, it is postulated that DSCAM-L1 is involved in the formation and maintenance of neural networks (1). Because of its chromosomal location, DSCAM-L1 is an ideal candidate for neuronal disorders such as Gilles de la Tourette and Jacobsen syndromes (1). DSCAM-L1 mediates homophilic adhesion and is involved in the formation of lamina-specific synaptic connections in the vertebrate retina (2).

Array 3315-DL

• DSCAM-L1 Antibodies
• DSCAM-L1 Proteins and Enzyme