Recombinant Human APLP-1 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Amyloid Precursor-like Proteins (APLPs) are members of the amyloid precursor protein (APP) superfamily of transmembrane proteins. APLP-1, APLP-2, and APP share highly homologous amino acid sequences, except that APLPs lack the beta -amyloid domain derived by proteolytic processing from APP (1). APLP-1 is expressed post-synaptically in cortical neurons (2). APLP-1 is post-translationally modified by N-glycosylation and displays an apparent molecular mass of 80-90 kDa in reducing SDS-PAGE (3). Similar to APP and APLP-2, APLP-1 is susceptible to cleavage by MMPs and secretases, generating multiple fragments from the extracellular and intracellular domains (4). These include peptides similar to the amyloidogenic A beta peptides and a cytoplasmic fragment that associates with Fe65 family proteins and functions as a transcriptional activator (4). The extracellular domain contains heparin and collagen binding regions. human APLP-1 shares 88% and 86% aa sequence identity with mouse and rat APLP-1, respectively.

Array 9605-AL

• APLP-1 Antibodies
• APLP-1 ELISA Kits
• APLP-1 Lysate
• APLP-1 Proteins
• APLP-1 Proteins and Enzyme