Recombinant Human 6-Phosphogluconate Dehydrogenase/PGD, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

6-phosphogluconate dehydrogenase (PGD) is the second dehydrogenase in the pentose phosphate pathway (1). It catalyzes the oxidative decarboxylation of
6-phosphogluconate to ribulose 5-phosphate and CO₂, with concomitant reduction of NADP to NADPH (2). Together with glucose-6-phosphate dehydrogenase (G6PD), these enzymes ensure the reducing environment of the cell cytoplasm (3). However, the activities of both enzymes are strongly inhibited by NADPH. It is not quite clear how the enzymes are regulated to maintain the level of reducing power inside cells (4). Deficiency of PGD is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of PGD and 6-phosphogluconolactonase suggest a synergism of the two enzymopathies (5).

Array 8964-DH

• PGD Antibodies
• PGD Lysate
• PGD Proteins
• PGD Proteins and Enzyme