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RB1 Antibody (RB1/1754) [PerCP]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications IHC
Clone
RB1/1754
Clonality
Monoclonal
Host
Mouse
Conjugate
PerCP

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-54476AF350
Alexa Fluor 405
NBP2-54476AF405
Alexa Fluor 488
NBP2-54476AF488
Alexa Fluor 532
NBP2-54476AF532
Alexa Fluor 594
NBP2-54476AF594
Alexa Fluor 647
NBP2-54476AF647
Alexa Fluor 700
NBP2-54476AF700
Alexa Fluor 750
NBP2-54476AF750
Allophycocyanin
NBP2-54476APC
Biotin
NBP2-54476B-0.1ml
DyLight 350
NBP2-54476UV-0.1ml
DyLight 405
NBP2-54476V-0.1ml
DyLight 488
NBP2-54476G
DyLight 550
NBP2-54476R
DyLight 594
NBP2-54476DL594
DyLight 650
NBP2-54476C
DyLight 680
NBP2-54476FR
DyLight 755
NBP2-54476IR-0.1ml
FITC
NBP2-54476F
HRP
NBP2-54476H
Janelia Fluor 549
NBP2-54476JF549
Janelia Fluor 646
NBP2-54476JF646
PE
NBP2-54476PE
Unconjugated
NBP2-53400-100ug
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-53400-100ug
Azide and BSA Free
NBP2-54476-100ug
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RB1 Antibody (RB1/1754) [PerCP] Summary

Immunogen
Recombinant human RB1 protein (Uniprot: P06400)
Localization
Nuclear
Specificity
Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It reacts with the hyper-phosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
RB1
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for RB1 Antibody (RB1/1754) [PerCP]

  • OSRC
  • osteosarcoma
  • p105-Rb
  • pp110
  • pRb
  • RB
  • RB1
  • retinoblastoma 1
  • retinoblastoma suspectibility protein
  • retinoblastoma-associated protein

Background

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of ts function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol RB1