PDGF R beta Antibody (42G12)

Mitogenic platelet derived growth factor (PDGF) signaling is mediated by the PDGF tyrosine kinase receptors PDGFRalpha and PDGFRbeta, which exist as homo- or heterodimer isoforms (alphaalpha, betabeta, alphabeta). Secretion of PDGFs and expression of PDGFRs in a broad distribution of cell types contributes to regulation of cellular processes including cell growth, actin reorganization, prevention of apoptosis, and chemotaxis. Structurally, the transmembrane PDGFRs are composed of an N-terminal extracellular domain with five immunoglobulin repeats, and an intracellular domain containing two spaced tyrosine kinase domains. PDGF ligands display preferential affinity to PDGFRalpha and PDGFRbeta, with PDGFRbeta activation restricted to binding by PDGF BB and PDGF DD. Growth factor binding initiates receptor dimerization and activates the cytosolic tyrosine kinase domains.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: KD, PLA.

Showing Publication 1 - 1 of 1.

Publication using NBP1-19191	Applications	Species
Kramer F, Dernedde J, Mezheyeuski A et al. Platelet-derived growth factor receptor beta activation and regulation in murine myelofibrosis Haematologica 2019-10-31 [PMID: 31672904] (KD, PLA, Mouse)	KD, PLA	Mouse

Array NBP1-19191

• PDGF R beta Antibodies
• PDGF R beta Antibody Pair
• PDGF R beta Lysate
• PDGF R beta Protein
• PDGF R beta Proteins and Enzymes
• PDGF R beta ELISAs