![PAX8 Antibody (PAX8/1491 + PAX8/1492) [mFluor Violet 450 SE] [NBP3-08274MFV450] - Vial of mFluor Violet 450 conjugated antibody. mFluor Violet 450 is optimally excited at 406 nm by the Violet laser (405 nm) and has an emission maximum of 445 nm.](http://images.novusbio.com/fullsize/nbp3-08274mfv450_mouse-pax8-mab-pax8-1491-pax8-1492-mfv450-se-226202312574428.png "PAX8 Antibody (PAX8/1491 + PAX8/1492) [mFluor Violet 450 SE] [NBP3-08274MFV450] - Vial of mFluor Violet 450 conjugated antibody. mFluor Violet 450 is optimally excited at 406 nm by the Violet laser (405 nm) and has an emission maximum of 445 nm.")
| Reactivity | HuSpecies Glossary |
| Applications | WB, Flow, ICC/IF, IHC |
| Clone | PAX8/1491 + PAX8/1492 |
| Clonality | Monoclonal |
| Host | Mouse |
| Conjugate | mFluor Violet 450 SE |
| Immunogen | Recombinant human PAX8 protein (Uniprot: Q06710) |
| Localization | Nuclear |
| Marker | Renal Cell Marker |
| Specificity | Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors. |
| Isotype | IgG2a Kappa/IgG2b Kappa |
| Clonality | Monoclonal |
| Host | Mouse |
| Gene | PAX8 |
| Purity | Protein A or G purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Dilutions |
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| Application Notes | Optimal dilution of this antibody should be experimentally determined. |
| Storage | Store at 4C in the dark. |
| Buffer | 50mM Sodium Borate |
| Preservative | 0.05% Sodium Azide |
| Purity | Protein A or G purified |
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Secondary Antibodies |
Isotype Controls |
Research Areas for PAX8 Antibody (NBP3-08274MFV450)Find related products by research area.
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| Gene Symbol | PAX8 |
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