Patched 1/PTCH Antibody [FITC]

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Patched 1 (PTCH1) acts as a receptor for SHH, IHH (indian hedgehog) and DHH (desert hedgehog) in SHH/sonic hedgehog signaling pathway which is critical in embryonic development, tissue patterning, and cell-fate decisions. SHH pathway activation is triggered by binding of SHH to PTCH1 (glycosylation being necessary for binding), which in the absence of SHH suppresses the activity of SMO (Smoothened protein), and this SHH- PTCH1 binding or mutational inactivation of PTCH1 relieves the inhibition of SMO culminating in the activation of one or more of GLI1 transcription factors that regulate the expression of downstream targets. PTCH1 mutations or its aberrant expression may leads to developmental defects and a cancer-prone phenotype. Mice partially deficient in functional PTCH1 exhibit developmental abnormalities that are comparable to those of nevoid basal cell carcinoma syndrome patients and additionally, these mice develop tumors such as medulloblastomas, rhabdomyosarcomas, and basal cell carcinomas following UV or ionizing radiation exposure. PTCH1 germline mutations in humans are responsible for nevoid basal cell carcinoma syndrome, also called Gorlin syndrome characterized by various developmental malformations and a high predisposition to skin basal cell carcinoma. Besides basal cell nevus syndrome (BCNS), defects in PTCH1 have been linked to sporadic basal cell carcinoma (BCC) and holoprosencephaly type 7 (HPE7).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP1-71662F

• Patched 1/PTCH Antibodies
• Patched 1/PTCH Lysate
• Patched 1/PTCH Proteins