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p21/CIP1/CDKN1A Antibody (CIP1/823) [DyLight 350]

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Product Details

Summary
Reactivity Hu, Mu(-), Rt(-)Species Glossary
Applications WB, ICC/IF, IHC
Clone
CIP1/823
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 350

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-47783AF350
Alexa Fluor 405
NBP2-47783AF405
Alexa Fluor 488
NBP2-47783AF488
Alexa Fluor 532
NBP2-47783AF532
Alexa Fluor 594
NBP2-47783AF594
Alexa Fluor 647
NBP2-47783AF647
Alexa Fluor 700
NBP2-47783AF700
Alexa Fluor 750
NBP2-47783AF750
Biotin
NBP2-47783B
DyLight 405
NBP2-47783V
DyLight 488
NBP2-47783G
DyLight 550
NBP2-47783R
DyLight 594
NBP2-47783DL594
DyLight 650
NBP2-47783C
DyLight 680
NBP2-47783FR
DyLight 755
NBP2-47783IR
FITC
NBP2-47783F
HRP
NBP2-47783H
Janelia Fluor 549
NBP2-47783JF549
Janelia Fluor 646
NBP2-47783JF646
Unconjugated
NBP2-44527-0.1mg
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-44527-0.1mg
Azide and BSA Free
NBP2-47783-0.1mg
IHC-Prediluted
NBP2-48371
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p21/CIP1/CDKN1A Antibody (CIP1/823) [DyLight 350] Summary

Description
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Immunogen
Recombinant full-length human p21/CIP1/CDKN1A protein (Uniprot: P38936)
Localization
Nuclear
Specificity
This monoclonal antibody recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This monoclonal antibody is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdks and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CDKN1A
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Does not react with Mouse or Rat.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for p21/CIP1/CDKN1A Antibody (CIP1/823) [DyLight 350]

  • CAP20cyclin-dependent kinase inhibitor 1
  • CDK-interacting protein 1
  • CDKN1A
  • CDKN1melanoma differentiation associated protein 6
  • CIP1
  • CIP1WAF1CDK-interaction protein 1
  • cyclin-dependent kinase inhibitor 1A (p21, Cip1)
  • MDA6
  • MDA-6
  • Melanoma differentiation-associated protein 6
  • p21
  • p21CIP1
  • p21Cip1/Waf1
  • PIC1
  • SDI1DNA synthesis inhibitor
  • wild-type p53-activated fragment 1

Background

Cell cycle progression is regulated by cyclins and their cognate Cdks. p21 (WAF1/CIP1) inhibits the activity of each member of the cyclin/Cdk family, and over expression of this protein inhibits the proliferation of mammalian cells. The expression of p21 is inducible by a wide range of stress stimuli. p21 is tightly regulated at the transcriptional level by p53, and probably serves as the effector of p53 cell cycle control.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CDKN1A