p21/CIP1/CDKN1A Antibody (CIP1/4377R) [Allophycocyanin]

Recombinant Monoclonal Antibody

Synthetic peptide corresponding to p21/CIP1/CDKN1A residues within aa1-100 of p21/CIP1/CDKN1A was used as an immunogen. (Uniprot: P38936 )

Nuclear

This monoclonal antibody recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This monoclonal antibody is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).

IgG

Monoclonal

Rabbit

CDKN1A

Protein A or G purified

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Optimal dilution of this antibody should be experimentally determined.