Numb Antibody Blocking Peptide Summary
Specificity |
This peptide is specific for NBP2-27181 only. |
Protein/Peptide Type |
Antibody Blocking Peptide |
Gene |
NUMB |
Applications/Dilutions
Dilutions |
|
Application Notes |
This peptide is useful as a blocking peptide for NBP2-27181. For further blocking peptide related protocol, click here. |
Packaging, Storage & Formulations
Storage |
Store at -80C. Avoid freeze-thaw cycles. |
Buffer |
Peptide dissolved in dH20. Contains no BSA. |
Preservative |
No Preservative |
Concentration |
1 mg/ml |
Alternate Names for Numb Antibody Blocking Peptide
Background
Numb is a transmembrane signaling receptor that is activated by the DSL family of ligands. Studies suggestthat mammalian Numb plays a role in progenitor cell fate in neurogenesis. Numb exerts its role on cell fate by antagonizing Notch signaling. The mammalian Numb gene undergoes alternative splicing to produce at least four functionally different Numb isoforms which regulate different processes. A loss of Numb expression has been demonstrated in breast cancer, non-small cell lung cancer and chronic myelogenous leukemia.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are
guaranteed for 3 months from date of receipt.
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