Numb Antibody Blocking Peptide Summary
Description |
A NUMB antibody blocking peptide. |
Specificity |
This peptide is specific for NB500-178 only. |
Protein/Peptide Type |
Antibody Blocking Peptide |
Gene |
NUMB |
Applications/Dilutions
Dilutions |
|
Application Notes |
This peptide is useful as a blocking peptide for NB500-178. For further blocking peptide related protocol, click here. |
Packaging, Storage & Formulations
Storage |
Store at -80C. Avoid freeze-thaw cycles. |
Buffer |
Peptide dissolved in dH2O. Contains no BSA. |
Preservative |
No Preservative |
Concentration |
1.0 mg/ml |
Alternate Names for Numb Antibody Blocking Peptide
Background
Numb is a transmembrane signaling receptor that is activated by the DSL family of ligands. Studies suggestthat mammalian Numb plays a role in progenitor cell fate in neurogenesis. Numb exerts its role on cell fate by antagonizing Notch signaling. The mammalian Numb gene undergoes alternative splicing to produce at least four functionally different Numb isoforms which regulate different processes. A loss of Numb expression has been demonstrated in breast cancer, non-small cell lung cancer and chronic myelogenous leukemia.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are
guaranteed for 3 months from date of receipt.
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