Numb Antibody (447716) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Numb is a member of a family of cytoplasmic adaptor proteins termed CLASPS (Clathran-associated Sorting Proteins). These link transmembrane cargo proteins to the endocytic machinery. Numb, a conserved cell-fate determining factor, is normally associated with the basolateral surface of polarized cells. Movement towards the apical surface induces its phosphorylation, which precludes its entry into this region. Human Numb is 651 amino acids (aa) in length. It contains one PTB (aa 24‑172) and one PRR (aa 366‑413) domain. There is a potential for multiple alternate splice forms that involve all regions of the molecule. Over aa 356‑592, human Numb shares 88% and 90% aa identity with mouse and canine Numb, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publication 1 - 1 of 1.

Publication using MAB4338	Applications	Species
Shao X, Liu Y, Yu Q et al. Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b. Cell Res. 2016-03-18 [PMID: 26987402] Details: SOD1/Cu-Zn SOD antibody (clone 6F5) was used for WB analysis of lysates from liver tissues of goldfish (Carassius auratus) subjected or not to melatonin injections or green-wavelength LED light (Fig. 4).

Array MAB4338

• Numb Antibodies
• Numb Lysates
• Numb Proteins