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Recombinant Human NRG4 His Protein

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SDS-Page: NRG4 Protein [NBP2-23278]

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
0.25 mg/ml

Order Details

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Recombinant Human NRG4 His Protein Summary

Description
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-61 of Human NRG4

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSMPTDHEE PCGPSHKSFC LNGGLCYVIP TIPSPFCRCV ENYTGARCEE VFLPGSSIQT KSNL

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
NRG4
Purity
>90%, by SDS-PAGE

Applications/Dilutions

Dilutions
  • SDS-Page
Theoretical MW
9.1 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20 mM Tris-HCl buffer (pH8.0), 30% glycerol, 0.15 M NaCl, 1 mM DTT
Preservative
No Preservative
Concentration
0.25 mg/ml
Purity
>90%, by SDS-PAGE

Alternate Names for Recombinant Human NRG4 His Protein

  • DKFZp779N0541
  • DKFZp779N1944
  • heregulin 4
  • HRG4pro-NRG4
  • neuregulin 4
  • pro-neuregulin-4, membrane-bound isoform
  • Pro-NRG4

Background

NRG4 belongs to the neuregulin family and contains 1 EGF-like domain. The protein is low affinity ligand for the ERBB4 tyrosine kinase receptor. It concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Recombinant human NRG4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol NRG4