Nicastrin Antibody Blocking Peptide Summary
Description |
A blocking peptide containing 18 amino acids near the center of human nicastrin. Source: Synthetic (Accession #: NP_056146) |
Source |
Synthetic |
Protein/Peptide Type |
Antibody Blocking Peptide |
Gene |
NCSTN |
Purity |
N/A |
Applications/Dilutions
Dilutions |
|
Application Notes |
This peptide is useful as a blocking peptide for NBP1-77270. For further blocking peptide related protocol, click here. |
Packaging, Storage & Formulations
Storage |
Store at -20C. Avoid freeze-thaw cycles. |
Buffer |
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin. |
Preservative |
0.02% Sodium Azide |
Concentration |
0.2 mg/ml |
Purity |
N/A |
Alternate Names for Nicastrin Antibody Blocking Peptide
Background
Nicastrin is a large protein that is a component of an enzyme called gamma-secretase, which is lodged in the cell's membrane. Nicastrin protein is physically associated with presenilin and plays an important role in stabilization and correct localization of presenilin to the membrane-bound gamma-secretase complex. Nicastrin also serves as a docking site for gamma-secretase substrates such as APP and Notch, directly binding to them and presenting them properly to gamma-secretase to ensure the correct cleavage process.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are
guaranteed for 3 months from date of receipt.
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