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Nicastrin Antibody [Janelia Fluor® 585]

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Summary
Product Discontinued
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    • Catalog Number
      NBP1-77270JF585
    • Availability
      Product Discontinued

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Nicastrin Antibody [Janelia Fluor® 585] Summary

Immunogen
Antibody was raised against a 18 amino acid synthetic peptide from near the center of human Nicastrin. The immunogen is located within amino acids 370 - 420 of Nicastrin. Amino Acid Squence: HTDPVSQKNESVRNQVED
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NCSTN
Purity
Peptide affinity purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Nicastrin Antibody [Janelia Fluor® 585]

  • anterior pharynx-defective 2
  • APH2
  • ATAG1874
  • KIAA0253APH2
  • NCSTN
  • Nicastrin

Background

Nicastrin is a large protein that is a component of an enzyme called gamma-secretase, which is lodged in the cell's membrane. Nicastrin protein is physically associated with presenilin and plays an important role in stabilization and correct localization of presenilin to the membrane-bound gamma-secretase complex. Nicastrin also serves as a docking site for gamma-secretase substrates such as APP and Notch, directly binding to them and presenting them properly to gamma-secretase to ensure the correct cleavage process.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol NCSTN