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Nicastrin Antibody [mFluor Violet 610 SE]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
mFluor Violet 610 SE

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-77269AF350
Alexa Fluor 405
NBP1-77269AF405
Alexa Fluor 488
NBP1-77269AF488
Alexa Fluor 532
NBP1-77269AF532
Alexa Fluor 594
NBP1-77269AF594
Alexa Fluor 647
NBP1-77269AF647
Alexa Fluor 700
NBP1-77269AF700
Alexa Fluor 750
NBP1-77269AF750
Biotin
NBP1-77269B
CoraFluor 1
NBP1-77269CL1
DyLight 350
NBP1-77269UV
DyLight 405
NBP1-77269V
DyLight 488
NBP1-77269G
DyLight 550
NBP1-77269R
DyLight 594
NBP1-77269DL594
DyLight 650
NBP1-77269C
DyLight 680
NBP1-77269FR
DyLight 755
NBP1-77269IR
FITC
NBP1-77269F
HRP
NBP1-77269H
Janelia Fluor 525
NBP1-77269JF525
Janelia Fluor 549
NBP1-77269JF549
Janelia Fluor 646
NBP1-77269JF646
Janelia Fluor 669
NBP1-77269JF669
PerCP
NBP1-77269PCP
Unconjugated
NBP1-77269
mFluor Violet 450 SE
NBP1-77269MFV450
mFluor Violet 500 SE
NBP1-77269MFV500
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-77269
BSA Free
NBP1-77269
BSA Free
NBP1-77269-0.025mg
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Nicastrin Antibody [mFluor Violet 610 SE] Summary

Immunogen
Antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human Nicastrin. The immunogen is located within amino acids 630 - 680 of Nicastrin. Amino Acid Squence: TEYSTWTESRWKDIRAR
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NCSTN
Purity
Peptide affinity purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Nicastrin Antibody [mFluor Violet 610 SE]

  • anterior pharynx-defective 2
  • APH2
  • ATAG1874
  • KIAA0253APH2
  • NCSTN
  • Nicastrin

Background

Nicastrin is a large protein that is a component of an enzyme called gamma-secretase, which is lodged in the cell's membrane. Nicastrin protein is physically associated with presenilin and plays an important role in stabilization and correct localization of presenilin to the membrane-bound gamma-secretase complex. Nicastrin also serves as a docking site for gamma-secretase substrates such as APP and Notch, directly binding to them and presenting them properly to gamma-secretase to ensure the correct cleavage process.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Bioinformatics

Gene Symbol NCSTN