Neurogranin Antibody (898502) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

NRGN (Neurogranin/Ng; also known as RC3, p17 and BICKS) is a member of the neurogranin family of proteins. Although its predicted MW is 7.5 kDa, it runs anomalously at 15-19 kDa in SDS-PAGE. This is apparently due to the adoption of a rigid alpha -helical structure in a negatively charged medium. NRGN has limited expression, being found principally in excitatory neurons of the telencephalon, Golgi and Purkinje cells of the cerebellum, and platelets plus B and T cells in non-nervous tissue. Intracellularly, NRGN is found associated with membranes of the ER, Golgi and mitochondria. This association is often in the form of aggregates (or granules), thus giving rise to its name ("neuro-granules"). NRGN is also found in the nucleus and associated with the postsynaptic spines of dendrites. The principal function of NRGN appears to be the binding, sequestration and concentration of CaM (Calmodulin; a Ca-binding protein) in dendritic spines. Following NMDAR activation, Ca diffuses into the synaptic area, resulting in 1) the simply dissociation of CaM from NRGN, or 2) the phosphorylation of NRGN followed by its dissociation fro CaM. In either case, the freed CaM is now available to activate multiple downstream signaling pathways, some involved in LTP (or memory). Human NRGN is 78 amino acids (aa) in length. It contains one IQ domain (aa 26-47) that binds CaM, and a collagen-like region at the C-terminus (aa 48-78). Regulatory phosphorylation occurs on Ser36, and the N-terminal Met is acetylated. Full-length human NRGN shares 96% aa sequence identity with both mouse and rat NRGN.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using MAB7947	Applications	Species
Kerstin Voelkl, Sara Gutiérrez-Ángel, Sophie Keeling, Seda Koyuncu, Miguel da Silva Padilha, Dennis Feigenbutz et al. Neuroprotective effects of hepatoma-derived growth factor in models of Huntington’s disease Life Science Alliance 2023-11-01 [PMID: 37580082]
Dick Jaarsma, Francois G. C. Blot, Bin Wu, Subramanian Venkatesan, Jan Voogd, Dies Meijer et al. The basal interstitial nucleus (BIN) of the cerebellum provides diffuse ascending inhibitory input to the floccular granule cell layer Journal of Comparative Neurology 2018-10-01 [PMID: 29943833]

Array MAB7947

• Neurogranin Antibodies
• Neurogranin ELISA Kits
• Neurogranin Lysates
• Neurogranin Proteins
• Neurogranin ELISA