Mouse/Rat SOST/Sclerostin Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

SOST, also known as Sclerostin, is a Cerberus/DAN family BMP antagonist and is an important regulator of bone homeostasis. Inactivating mutations in the SOST gene can cause sclerosteosis and van Buchem disease. SOST is expressed by terminally differentiated cells embedded in mineralized matrix including osteocytes, hypertrophic and prehypertrophic chondrocytes, and tooth cementocytes. Its expression is induced by BMP-2, -4, and -6 and is inhibited by parathyroid hormone (PTH). Its downregulation in osteocytes by physical loading of bone contributes to the mechanical sensor function of osteocytes and the subsequent increase in bone growth. SOST binds to BMP-2, -4, -5, -6, and -7 and inhibits the osteogenic differentiation induced by these BMPs. It inhibits canonical Wnt signaling by binding to LRP-5 and LRP-6 and inhibiting their association with Frizzled receptors. SOST reduces the proliferation of mesenchymal stem cells (MSC) and induces MSC apoptosis. Circulating levels of SOST are elevated in pathologies with bone involvement including low bone mineral density, Paget’s disease, multiple myeloma, and prostate cancer with bone metastases. It is also elevated in advanced chronic kidney disease, alcoholic liver disease, type 2 diabetes, and patients with increased abdominal and gynoid fat.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using MSST00	Applications	Species
Sakamoto, E;Kitase, Y;Fitt, AJ;Zhu, Z;Awad, K;Brotto, M;White, KE;Welc, SS;Bergwitz, C;Bonewald, LF; Both enantiomers of ?-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes Cell reports 2024-06-25 [PMID: 38935499] (Mouse)		Mouse
Jolic, M;Ruscsák, K;Emanuelsson, L;Norlindh, B;Thomsen, P;Shah, FA;Palmquist, A; Leptin receptor gene deficiency minimally affects osseointegration in rats Scientific reports 2023-09-20 [PMID: 37730735] (Rat)		Rat
Ewendt, F;Lehmann, A;Wodak, MF;Stangl, GI; All-trans Retinoic Acid and Beta-Carotene Increase Sclerostin Production in C2C12 Myotubes Biomedicines 2023-05-12 [PMID: 37239103] (Mouse)		Mouse
N Kurgan, B Baranowski, J Stoikos, AJ MacNeil, VA Fajardo, REK MacPherson, P Klentrou Characterization of sclerostin's response within white adipose tissue to an obesogenic diet at rest and in response to acute exercise in male mice Frontiers in Physiology, 2023-01-04;13(0):1061715. 2023-01-04 [PMID: 36685192] (Mouse)		Mouse
H Chai, ZH Zhang, JY Fang, C She, C Geng, W Xu Osteocytic cells exposed to titanium particles increase sclerostin expression and inhibit osteoblastic cell differentiation mostly via direct cell-to-cell contact Journal of Cellular and Molecular Medicine, 2022-06-28;0(0):. 2022-06-28 [PMID: 35762300] (Mouse)		Mouse
T Moriishi, T Ito, R Fukuyama, X Qin, H Komori, H Kaneko, Y Matsuo, N Yoshida, T Komori Sp7 Transgenic Mice with a Markedly Impaired Lacunocanalicular Network Induced Sost and Reduced Bone Mass by Unloading International Journal of Molecular Sciences, 2022-03-15;23(6):. 2022-03-15 [PMID: 35328592] (Mouse)		Mouse
N Kurgan, H Islam, JBL Matusiak, BJ Baranowski, J Stoikos, VA Fajardo, REK MacPherson, BJ Gurd, P Klentrou Subcutaneous adipose tissue sclerostin is reduced and Wnt signaling is enhanced following 4-weeks of sprint interval training in young men with obesity Physiological Reports, 2022-03-01;10(6):e15232. 2022-03-01 [PMID: 35312183] (Human)		Human
CC Lee, CM Hung, CH Chen, YC Hsu, YP Huang, TB Huang, MJ Lee Novel Aptamer-Based Small-Molecule Drug Screening Assay to Identify Potential Sclerostin Inhibitors against Osteoporosis International Journal of Molecular Sciences, 2021-08-02;22(15):. 2021-08-02 [PMID: 34361085] (Mouse)		Mouse
M Koide, T Yamashita, K Murakami, S Uehara, K Nakamura, M Nakamura, M Matsushita, T Ara, H Yasuda, JM Penninger, N Takahashi, N Udagawa, Y Kobayashi Sclerostin expression in trabecular bone is downregulated by osteoclasts Sci Rep, 2020-08-13;10(1):13751. 2020-08-13 [PMID: 32792620] (Mouse)		Mouse
X Gao, A Lu, Y Tang, J Schneppend, AB Liebowitz, AC Scibetta, ER Morris, H Cheng, C Huard, S Amra, B Wang, MA Hall, WR Lowe, J Huard Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration Stem Cell Res Ther, 2018-11-21;9(1):316. 2018-11-21 [PMID: 30463597] (Mouse)		Mouse
K Ogura, T Iimura, Y Makino, A Sugie-Oya, A Takakura, R Takao-Kawa, T Ishizuya, K Moriyama, A Yamaguchi Short-term intermittent administration of parathyroid hormone facilitates osteogenesis by different mechanisms in cancellous and cortical bone Bone Rep, 2016-01-16;5(0):7-14. 2016-01-16 [PMID: 28326342] (Rat)		Rat
L Xiong, JU Jung, HH Guo, JX Pan, XD Sun, L Mei, WC Xiong Osteoblastic Lrp4 promotes osteoclastogenesis by regulating ATP release and adenosine-A2AR signaling J. Cell Biol, 2017-02-13;0(0):. 2017-02-13 [PMID: 28193701] (Mouse)		Mouse
Frank C Ko Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice J Bone Miner Res, 2016-11-07;0(0):. 2016-11-07 [PMID: 27324177] (Mouse)		Mouse
Sinnesael M, Laurent M, Jardi F, Dubois V, Deboel L, Delisser P, Behets G, D'Haese P, Carmeliet G, Claessens F, Vanderschueren D Androgens inhibit the osteogenic response to mechanical loading in adult male mice. Endocrinology, 2015-02-05;156(4):1343-53. 2015-02-05 [PMID: 25654322] (Mouse)		Mouse
Beggs L, Ye F, Ghosh P, Beck D, Conover C, Balaez A, Miller J, Phillips E, Zheng N, Williams A, Aguirre J, Wronski T, Bose P, Borst S, Yarrow J Sclerostin inhibition prevents spinal cord injury-induced cancellous bone loss. J Bone Miner Res, 2015-04-01;30(4):681-9. 2015-04-01 [PMID: 25359699] (Rat)		Rat
Liu S, Song W, Boulanger J, Tang W, Sabbagh Y, Kelley B, Gotschall R, Ryan S, Phillips L, Malley K, Cao X, Xia T, Zhen G, Cao X, Ling H, Dechow P, Bellido T, Ledbetter S, Schiavi S Role of TGF-beta in a mouse model of high turnover renal osteodystrophy. J Bone Miner Res, 2014-01-01;29(5):1141-57. 2014-01-01 [PMID: 24166835] (Mouse)		Mouse
Show All 16 Publications. Collapse Publications.

Array MSST00

• SOST/Sclerostin Antibodies
• SOST/Sclerostin Lysate
• SOST/Sclerostin Proteins and Enzymes
• SOST/Sclerostin ELISAs