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Methyltransferase like 3 Antibody

 (16 Publications)
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Western Blot: Methyltransferase like 3 Antibody [H00056339-B01P] - Analysis of METTL3 expression in human colon.
Western Blot: Methyltransferase like 3 Antibody [H00056339-B01P] - Analysis of METTL3 expression in human colon.
Immunocytochemistry/ Immunofluorescence: Methyltransferase like 3 Antibody [H00056339-B01P] - purified antibody to METTL3 on HeLa cell. [antibody concentration 10 ug/ml]
Western Blot: Methyltransferase like 3 Antibody [H00056339-B01P] - Analysis of METTL3 expression in transfected 293T cell line by METTL3 polyclonal antibody. Lane 1: METTL3 transfected lysate(63.8 KDa). Lane 2: ...read more

Product Details

Summary
Reactivity Hu, Mu, PmSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Mouse
Conjugate
Unconjugated

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Methyltransferase like 3 Antibody Summary

Immunogen
METTL3 (NP_062826.2, 1 a.a. - 580 a.a.) full-length human protein. MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSPTFRSDSPVPTAPTSGGPKPSTASAVPELATDPELEKKLLHHLSDLALTLPTDAVSICLAISTPDAPATQDGVESLLQKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVAEKKGPGEVAGTVTGQKRRAEQDSTTVAAFASSLVSGLNSSASEPAKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSKKVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDADRPCRKLHFRRIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACMDSEAPGSKDHTPSQELALTQSVGGDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKPKNL
Specificity
NM_019852.3
Isotype
IgG
Clonality
Polyclonal
Host
Mouse
Gene
METTL3
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 10 ug/ml
  • Western Blot 1:1000
Application Notes
Antibody reactive against mammalian transfected lysate.
Publications
Read Publications using
H00056339-B01P in the following applications:

  • WB
    2 publications

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Methyltransferase like 3 Antibody

  • adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
  • EC 2.1.1.62
  • IME4
  • M6A
  • methyltransferase like 3
  • Methyltransferase-like protein 3
  • MGC4336
  • mRNA m(6)A methyltransferase
  • MTA70
  • MT-A70
  • N6-adenosine-methyltransferase 70 kDa subunit
  • Spo8

Background

Methyltransferase like 3 encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Methyltransferase like 3 Antibody (H00056339-B01P)(16)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.


Filter By Application
WB
(2)
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Filter By Species
Human
(3)
All Species
Showing Publications 1 - 10 of 16. Show All 16 Publications.
Publications using H00056339-B01P Applications Species
Douglas M. McLaurin, Sara K. Tucker, Michael D. Hebert Coilin mediates m 6 A RNA methylation through phosphorylation of METTL3 Biology Open 2023-12-15 [PMID: 38050869]
Perez-Pepe, M;Desotell, AW;Li, H;Li, W;Han, B;Lin, Q;Klein, DE;Liu, Y;Goodarzi, H;Alarc�n, CR; 7SK methylation by METTL3 promotes transcriptional activity Science advances 2023-05-10 [PMID: 37163588]
Leiming D, Yuanhui M, Aidong Z et al. Relaxed initiation pausing of ribosomes drives oncogenic translation. Sci Adv. 2021-02-17 [PMID: 33597240]
Gokhale NS, McIntyre ABR, Mattocks MD et al. Altered m6A modification of specific cellular transcripts affects Flaviviridae infection Mol Cell 2019-12-08 [PMID: 31810760]
Mao Y, Dong L, Liu X et al. m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2. Nat Commun. 2019-11-25 [PMID: 31767846]
Abhirami V, Vikas P, Shibla A et al. N<sup>6</sup>-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling. Genes (Basel). 2019-02-13 [PMID: 30781903]
Merkurjev D, Hong WT, Iida K et al. Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts. Nat Neurosci 2018-06-27 [PMID: 29950670]
Yu J, Li Y, Wang T, Zhong X. Modification of N6-methyladenosine RNA methylation on heat shock protein expression PLoS ONE 2018-06-14 [PMID: 29902206] (WB, Human) WB Human
Kobayashi M, Ohsugi M, Sasako T et al. The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis. Mol Cell Biol 2018-06-04 [PMID: 29866655]
Tsai K, Courtney D, Cullen B et al. Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication. PLoS Pathog. 2018-02-15 [PMID: 29447282]
Show All 16 Publications.

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Bioinformatics

Gene Symbol METTL3