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IL-4 Antibody (11B11) [DyLight 488] - Chimeric

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications ELISA, Flow, Func, IHC, CyTOF-ready
Clone
11B11
Clonality
Monoclonal
Host
Rabbit
Conjugate
DyLight 488

Order Details

IL-4 Antibody (11B11) [DyLight 488] - Chimeric Summary

Additional Information
Recombinant Monoclonal Antibody.
Immunogen
BSF-1 / IL-4 purified from serum-free supernatants of cultured EL-4 cells (a C57BL/6 thymoma) induced with 4 Beta-phorbol 12 Beta-myristate 12 alpha -acetate for 48h.
Specificity
Binds to a core functional region of murine IL-4, which prevents this cytokine from interacting with its cognate receptor (Yao et al., 2006 PMID: 16361318).
Isotype
IgG Kappa
Clonality
Monoclonal
Host
Rabbit
Gene
IL4
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • ELISA
  • Flow Cytometry
  • Immunohistochemistry
  • In vivo assay
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Mouse

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for IL-4 Antibody (11B11) [DyLight 488] - Chimeric

  • B cell growth factor 1
  • BCDF
  • B-cell stimulatory factor 1
  • BCGF1
  • BCGF-1
  • binetrakin
  • BSF1
  • BSF-1
  • IL4
  • IL-4
  • IL-4B_cell stimulatory factor 1
  • IL4E12
  • interleukin 4
  • interleukin-4
  • Lymphocyte stimulatory factor 1
  • MGC79402
  • pitrakinra

Background

IL-4 (Interleukin 4, B cell stimulatory factor) is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. IL-4 has many different functions including promoting proliferation and differentiation of immunologically competent cells. One of its main functions is regulating differentiation of naive CD4+ T cells into helper Th2 cells, the other main function is regulating B cells IgE and IgG1 production. Human IL-4 shows 50% homology with mouse IL-4, but its activities are species-specific and human IL-4 shows no activity on murine and rat cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol IL4