Human VISTA/B7-H5/PD-1H DuoSet ELISA, 5 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

VISTA, also known as B7-H5, PD-1H, platelet receptor Gi24, Dies1, and SISP1, is a transmembrane glycoprotein that promotes both MT1-MMP expression and the MT1-MMP mediated activation of MMP-2. VISTA supports the differentiation of embryonic stem cells (ESC) and enhances BMP-4 induced signaling in ESC but is also downregulated following BMP-4 exposure. It binds to BMP-4 directly and also associates with the type I BMP receptor Activin RIB/ALK-4. VISTA is expressed on the surface of naïve CD4+ T cells, regulatory T cells, and adipocytes. It is upregulated in vivo on activated monocytes and dendritic cells. VISTA inhibits CD4+ and CD8+ T cell proliferation and their production of IL-2 and IFN-gamma. Its expression on tumor cells attenuates the anti-tumor immune response and enables more rapid tumor progression. In contrast, VISTA limits disease progression in the autoimmune disease model EAE.

We have publications tested in 2 confirmed species: Human, E. coli.

Showing Publications 1 - 2 of 2.

Publications using DY7126-05	Applications	Species
A Gameiro, C Nascimento, J Correia, F Ferreira VISTA Is a Diagnostic Biomarker and Immunotherapy Target of Aggressive Feline Mammary Carcinoma Subtypes Cancers, 2021-11-05;13(21):. 2021-11-05 [PMID: 34771722] (Human)		Human
S Schlichtne, NH Meyer, IM Yasinska, N Aliu, SM Berger, BF Gibbs, E Fasler-Kan, VV Sumbayev Functional role of galectin-9 in directing human innate immune reactions to Gram-negative bacteria and T cell apoptosis International immunopharmacology, 2021-09-17;100(0):108155. 2021-09-17 [PMID: 34543981] (E. coli)		E. coli

Array DY7126-05

• VISTA/B7-H5/PD-1H Antibodies
• VISTA/B7-H5/PD-1H Lysate
• VISTA/B7-H5/PD-1H Proteins
• VISTA/B7-H5/PD-1H Proteins and Enzymes
• VISTA/B7-H5/PD-1H ELISA