Human SOST/Sclerostin Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

SOST, also known as Sclerostin, is a Cerberus/DAN family BMP antagonist and is an important regulator of bone homeostasis. Inactivating mutations in the SOST gene can cause sclerosteosis and van Buchem disease. SOST is expressed by terminally differentiated cells embedded in mineralized matrix including osteocytes, hypertrophic and prehypertrophic chondrocytes, and tooth cementocytes. Its expression is induced by BMP-2, -4, and -6 and is inhibited by parathyroid hormone (PTH). Its downregulation in osteocytes by physical loading of bone contributes to the mechanical sensor function of osteocytes and the subsequent increase in bone growth. SOST binds to BMP-2, -4, -5, -6, and -7 and inhibits the osteogenic differentiation induced by these BMPs. It inhibits canonical Wnt signaling by binding to LRP-5 and LRP-6 and inhibiting their association with Frizzled receptors. SOST reduces the proliferation of mesenchymal stem cells (MSC) and induces MSC apoptosis. Circulating levels of SOST are elevated in pathologies with bone involvement including low bone mineral density, Paget’s disease, multiple myeloma, and prostate cancer with bone metastases. It is also elevated in advanced chronic kidney disease, alcoholic liver disease, type 2 diabetes, and patients with increased abdominal and gynoid fat.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using DSST00	Applications	Species
C Papagoras, S Tsiami, A Chrysantho, I Mitroulis, X Baraliakos Serum granulocyte-macrophage colony-stimulating factor (GM-CSF) is increased in patients with active radiographic axial spondyloarthritis and persists despite anti-TNF treatment Arthritis Research & Therapy, 2022-08-16;24(1):195. 2022-08-16 [PMID: 35974380] (Human)		Human
Y Yu, L Wang, S Ni, D Li, J Liu, HY Chu, N Zhang, M Sun, N Li, Q Ren, Z Zhuo, C Zhong, D Xie, Y Li, ZK Zhang, H Zhang, M Li, Z Zhang, L Chen, X Pan, W Xia, S Zhang, A Lu, BT Zhang, G Zhang Targeting loop3 of sclerostin preserves its cardiovascular protective action and promotes bone formation Nature Communications, 2022-07-22;13(1):4241. 2022-07-22 [PMID: 35869074] (Mouse, Rat)		Mouse, Rat
J Rademacher, M Siderius, L Gellert, FR Wink, M Verba, F Maas, LM Tietz, D Poddubnyy, A Spoorenber, S Arends Baseline serum biomarkers of inflammation, bone turnover and adipokines predict spinal radiographic progression in ankylosing spondylitis patients on TNF inhibitor therapy Seminars in arthritis and rheumatism, 2022-02-02;53(0):151974. 2022-02-02 [PMID: 35150984] (Human)		Human
M Sylvawani, B Setyohadi, D Purnamasar, M Abdullah, MR Kurniawan Comparison of insulin-like growth factor-1 and sclerostin levels between premenopausal women with and without diabetes mellitus Journal of Taibah University Medical Sciences, 2021-06-11;16(5):719-723. 2021-06-11 [PMID: 34690653] (Human)		Human
CA Nava-Valdi, JM Ponce-Guar, AM Saldaña-Cr, EG Corona-San, M Ramirez-Vi, EE Perez-Guer, JD Murillo-Sa, B Contreras-, ML Vazquez-Vi, F Gonzalez-P, D Bonilla-La, H Jacobo-Cue, JD Centeno-Va, G Echeverria, S Cerpa-Cruz, MF Alcaraz-Lo, EG Cardona-Mu, M Salazar-Pa, L Gonzalez-L, JI Gamez-Nava Assessment of Serum sRANKL, sRANKL/OPG Ratio, and Other Bone Turnover Markers with the Estimated 10-Year Risk of Major and Hip Osteoporotic Fractures in Rheumatoid Arthritis: A Cross-Sectional Study BioMed Research International, 2021-08-30;2021(0):5567666. 2021-08-30 [PMID: 34497849] (Human)		Human
J Kim, W Han, T Park, EJ Kim, I Bang, HS Lee, Y Jeong, K Roh, J Kim, JS Kim, C Kang, C Seok, JK Han, HJ Choi Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains Nat Commun, 2020-10-23;11(1):5357. 2020-10-23 [PMID: 33097721] (Human)		Human
M Diani, S Perego, V Sansoni, L Bertino, M Gomarasca, M Faraldi, PDM Pigatto, G Damiani, G Banfi, G Altomare, G Lombardi Differences in Osteoimmunological Biomarkers Predictive of Psoriatic Arthritis among a Large Italian Cohort of Psoriatic Patients Int J Mol Sci, 2019-11-10;20(22):. 2019-11-10 [PMID: 31717649] (Human)		Human
R Kouvelioti, N Kurgan, B Falk, WE Ward, AR Josse, P Klentrou Response of Sclerostin and Bone Turnover Markers to High Intensity Interval Exercise in Young Women: Does Impact Matter? Biomed Res Int, 2018-11-01;2018(0):4864952. 2018-11-01 [PMID: 30515401] (Human)		Human
P Klentrou, K Angrish, N Awadia, N Kurgan, R Kouvelioti, B Falk Wnt Signaling-Related Osteokines at Rest and Following Plyometric Exercise in Prepubertal and Early Pubertal Boys and Girls Pediatr Exerc Sci, 2018-04-23;0(0):1-9. 2018-04-23 [PMID: 29683771] (Human)		Human
A Di Nisio, L De Toni, MS Rocca, M Ghezzi, R Selice, G Taglialavo, A Ferlin, C Foresta Negative Association Between Sclerostin and INSL3 in Isolated Human Osteocytes and in Klinefelter Syndrome: New Hints for Testis-Bone Crosstalk J. Clin. Endocrinol. Metab., 2018-05-01;0(0):. 2018-05-01 [PMID: 29452406] (Human)		Human
CC Niu, SS Lin, LJ Yuan, LH Chen, CY Yang, AN Chung, ML Lu, TT Tsai, PL Lai, WJ Chen Correlation of blood bone turnover biomarkers and Wnt signaling antagonists with AS, DISH, OPLL, and OYL BMC Musculoskelet Disord, 2017-02-02;18(1):61. 2017-02-02 [PMID: 28153008] (Human)		Human
Matthew T Drake Hormonal and systemic regulation of sclerostin Bone, 2016-12-10;0(0):. 2016-12-10 [PMID: 27965160] (Human)		Human
Show All 12 Publications. Collapse Publications.

Array DSST00

• SOST/Sclerostin Antibodies
• SOST/Sclerostin Lysate
• SOST/Sclerostin Proteins and Enzymes
• SOST/Sclerostin ELISAs