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HAI-2/SPINT2 Antibody [Biotin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA(Det)
Clonality
Polyclonal
Host
Goat
Conjugate
Biotin
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Unconjugated
AF1106
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
AF1106
Carrier Free
AF1106
Carrier Free
AF1106-SP
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HAI-2/SPINT2 Antibody [Biotin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human HAI-2A (R&D Systems, Catalog # 1106-PI)
Ala28-Lys197
Accession # O43291
Specificity
Detects human HAI-2 in ELISAs and Western blots. In sandwich immunoassays, less than 0.1% cross-reactivity with recombinant mouse HAI-2B and recombinant human HAI-1 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SPINT2
Purity Statement
Antigen Affinity-purified
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Applications/Dilutions

Dilutions
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
  • Western Blot 0.1 ug/mL
Application Notes
ELISA Capture: Human HAI-2 Ectodomain Antibody (Catalog # MAB1106)
ELISA Detection: Human HAI-2 Biotinylated Antibody (Catalog # BAF1106)
Standard:Recombinant Human HAI-2A (Catalog # 1106-PI)
Readout System

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for HAI-2/SPINT2 Antibody [Biotin]

  • HAI2
  • HAI-2
  • HAI-2DIAR3
  • HAI2FLJ45571
  • Hepatocyte growth factor activator inhibitor type 2
  • Kop
  • kunitz-type protease inhibitor 2
  • PB
  • Placental bikunin
  • serine peptidase inhibitor, Kunitz type, 2
  • serine protease inhibitor, Kunitz type, 2

Background

Two alternatively spliced forms of HAI-2 have been found in human tissues (1). HAI-2A, the full-length molecule and also known as placental bikunin, is a major form expressed in human tissues. Encoded by the SPINT2 gene, HAI-2A consists of two Kunitz domains, and a C-terminal transmembrane domain (1 - 5). Both Kunitz domains can function as inhibitors independent of each other. In addition to HGF activator and trysin, HAI-2A strongly inhibits plasmin, tissue and plasma kallikreins, and factor XIa. In comparison, HAI-2A is a weaker inhibitor of factor VIIa-tissue factor, factors IXa, Xa, and XIIa.

  1. Kataoka, H. et al. (2002) Biochem. Biophys. Res. Comm. 290:1096.
  2. Kawaguchi, T. et al. (1997) J. Biol. Chem. 272:27558.
  3. Marlor. C.W. et al. (1997) J. Biol. Chem. 272:12202.
  4. Muller-Pillasch, F. et al. (1998) Biochim. Biophys. Acta 1395:88.
  5. Delaria, K.A. et al. (1997) J. Biol. Chem. 272:12209.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SPINT2
Uniprot