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FoxP1 Antibody

 (13 Publications)
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Western blot shows lysates of Daudi human Burkitt's lymphoma cell line. Gels were loaded with 30 µg of whole cell lysate (WCL), 20 µg of cytoplasmic (Cyto), and 10 µg of nuclear extracts (Nuc). PVDF membrane was probed with 1 µg/mL Goat Anti-Human FoxP1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4534) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band for FoxP1 was detected at approximately 82 - 90 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Western blot shows lysates of Daudi human Burkitt's lymphoma cell line. Gels were loaded with 30 µg of whole cell lysate (WCL), 20 µg of cytoplasmic (Cyto), and 10 µg of nuclear extracts (Nuc). PVDF membrane was ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
AF4534-SP
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FoxP1 Antibody Summary

Immunogen
E. coli-derived recombinant human FoxP1
Leu231-Gly420
Accession # Q9H334
Specificity
Detects human FoxP1 in Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
FOXP1
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Publications
Read Publications using
AF4534 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FoxP1 Antibody

  • FLJ23741
  • fork head-related protein like B
  • forkhead box P1
  • forkhead box protein P1
  • FoxP1
  • glutamine-rich factor 1
  • hFKH1B
  • HSPC215
  • MGC12942
  • MGC88572
  • MGC99551
  • QRF1
  • QRF112CC4

Background

Forkhead Box P1 (FOXP1) is a member of the FOX family of transcription factors. FoxP1 has been implicated in cardiac, lung, and lymphocyte development. FoxP1 knock out mice die at embryonic day 14.5 due to heart valve and outflow tract abnormalities. FoxP1 contains both a DNA binding domain as well as protein-protein interaction domains. FoxP1 can homo or heterodimeize with FoxP2 and FoxP4, with dimerization necessary for DNA binding. FoxP1 shows both oncogenic and tumor suppressive characteristics. Overexpression in lymphomas leads to poor prognosis, whereas, loss of FoxP1 in breast cancer also implicates a poor prognosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for FoxP1 Antibody (AF4534)(13)

We have publications tested in 2 confirmed species: Mouse, Transgenic Mouse.

We have publications tested in 4 applications: Flow Cytometry, IHC, IHC-Fr, Immunohistochemistry.


Filter By Application
Flow Cytometry
(1)
IHC
(3)
IHC-Fr
(3)
Immunohistochemistry
(1)
All Applications
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Mouse
(7)
Transgenic Mouse
(1)
All Species
Showing Publications 1 - 10 of 13. Show All 13 Publications.
Publications using AF4534 Applications Species
Gauberg, J;Moreno, KB;Jayaraman, K;Abumeri, S;Jenkins, S;Salazar, AM;Meharena, HS;Glasgow, SM; Spinal motor neuron development and metabolism are transcriptionally regulated by Nuclear Factor IA bioRxiv : the preprint server for biology 2024-06-26 [PMID: 38979382] (Immunohistochemistry, Transgenic Mouse) Immunohistochemistry Transgenic Mouse
ES Liau, S Jin, YC Chen, WS Liu, M Calon, S Nedelec, Q Nie, JA Chen Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons Oncogene, 2023-01-03;14(1):46. 2023-01-03 [PMID: 36596814] (IHC, Mouse) IHC Mouse
Louise Thiry, Jean-Pierre Clément, Rainer Haag, Timothy E Kennedy, Stefano Stifani Optimization of Long-Term Human iPSC-Derived Spinal Motor Neuron Culture Using a Dendritic Polyglycerol Amine-Based Substrate ASN Neuro 2022-01-13 [PMID: 35023784]
M Toch, A Harris, O Schakman, E Kondratska, JL Boulland, N Dauguet, S Debrulle, C Baudouin, M Hidalgo-Fi, A Gow, JC Glover, F Tissir, F Clotman Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits Sci Rep, 2020-01-22;10(1):996. 2020-01-22 [PMID: 31969659] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Gauhar Masgutova, Audrey Harris, Benvenuto Jacob, Lynn M. Corcoran, Frédéric Clotman Pou2f2 Regulates the Distribution of Dorsal Interneurons in the Mouse Developing Spinal Cord Frontiers in Molecular Neuroscience 2019-11-07 [PMID: 31787878]
Audrey Harris, Gauhar Masgutova, Amandine Collin, Mathilde Toch, Maria Hidalgo-Figueroa, Benvenuto Jacob et al. Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord Frontiers in Cellular Neuroscience 2019-06-05 [PMID: 31231191]
KU Kabayiza, G Masgutova, A Harris, V Rucchin, B Jacob, F Clotman The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development Front Mol Neurosci, 2017-05-26;10(0):157. 2017-05-26 [PMID: 28603487] (IHC, Mouse) IHC Mouse
The role of Sema3-Npn-1 signaling during diaphragm innervation and muscle development J Cell Sci, 2016-07-27;0(0):. 2016-07-27 [PMID: 27466379] (IHC-Fr, Mouse) IHC-Fr Mouse
Jeffry M. Cesario, Asma A. Almaidhan, Juhee Jeong Expression of forkhead box transcription factor genes Foxp1 and Foxp2 during jaw development Gene Expression Patterns 2016-03-09 [PMID: 26969076]
Francius C, Harris A, Rucchin V et al. Identification of Multiple Subsets of Ventral Interneurons and Differential Distribution along the Rostrocaudal Axis of the Developing Spinal Cord. PLoS One. 8/15/2013 [PMID: 23967072]
Show All 13 Publications.

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Bioinformatics

Gene Symbol FOXP1
Uniprot