FLAP Antibody

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC, IHC-Fr, WB.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NB300-891	Applications	Species
Helgadottir A, Manolescu A, Thorleifsson G et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet 2004-03-01 [PMID: 14770184]
Huang YH. Impact of the arachidonic acid/leukotriene signaling pathway for vasculogenesis and leukocyte differentiation of mouse embryonic stem cells. thesis. 2015-10-26 (WB, Mouse)	WB	Mouse
Waghray A, Monga I, Lin B et al. A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epithelium bioRxiv 2023-11-29 [PMID: 38076853] (IHC, Human)	IHC	Human
Mrowetz H, Kotob MH, Forster J et al. Leukotriene signaling as molecular correlate for cognitive heterogeneity in aging: an exploratory study Frontiers in Aging Neuroscience 2023-08-02 [PMID: 37600518]
Schmider Ab, Bauer Nc, Sunwoo H et Al. Two and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils J. Biol. Chem. 2020-03-09 [PMID: 32152223]
SchUtz B, Ruppert AL, Strobel O et al. Distribution pattern and molecular signature of cholinergic tuft cells in human gastro-intestinal and pancreatic-biliary tract Sci Rep 2019-11-25 [PMID: 31767912] (ICC/IF, Human)	ICC/IF	Human
Schmider AB, Vaught M, Bauer NC, Elliott HL. The organization of leukotriene biosynthesis on the nuclear envelope revealed by single molecule localization microscopy and computational analyses bioRxiv 1905-07-11 [PMID: 30735559] (ICC/IF, Rat)	ICC/IF	Rat
Montoro D T, Haber A L et al. A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature 2018-01-08 [PMID: 30069044] (IF/IHC, Mouse)	IF/IHC	Mouse
Huang YH, Sharifpanah F, Becker S et al. Impact of Arachidonic Acid and the Leukotriene Signaling Pathway on Vasculogenesis of Mouse Embryonic Stem Cells. Cells Tissues Organs. 2016-05-31 [PMID: 27198524] (WB, Mouse)	WB	Mouse
Finkensieper A, Kieser S, Bekhite MM et al. The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells. Cardiovasc Res. 2010-04-01 [PMID: 19965960] (WB, Mouse) Details: BLT1 (IMG-71194) WB (mouse embryonic stem cell).	WB	Mouse
Widmayer P, Pregitzer P, Breer H Short-term high fat feeding induces inflammatory responses of tuft cells and mucosal barrier cells in the murine stomach Histology and histopathology 2022-07-29 [PMID: 35904321] (IHC-Fr, Mouse) Details: Dilution used for IHC 1:300	IHC-Fr	Mouse
Show All 12 Publications. Collapse Publications.

Array NB300-891

• FLAP Antibodies
• FLAP Lysate
• FLAP Proteins