May I know if NB110-41084 is specific only to the gamma chain of Hemoglobin F and does not exhibit cross-reactivity with the Hemoglobin A chain? There are several anti-hemoglobin F antibodies on the market that exhibit cross-reactivity with the A chain; we are looking for an antibody that does NOT exhibit residual activity with the A chain.

Name: Fetal Hemoglobin Antibody - BSA Free
Brand: Novus Biologicals
SKU: NB110-41084
Price: 409 USD

Question

Accepted Answer

For NB110-41084 please see Summary section of the datasheet. Specificity: "Hemoglobin F. No antibody was detected against hemoglobin A1, A2, S or human serum proteins." It appears that from testing, this antibody does not cross-react with Hemoglobin A1 or A2.

At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, ELISA
Clonality	Polyclonal
Host	Sheep
Conjugate	Unconjugated
Format	BSA Free
Concentration	1.0 mg/ml

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 NB110-41084AF350

Alexa Fluor 405 NB110-41084AF405

Alexa Fluor 488 NB110-41084AF488

Alexa Fluor 532 NB110-41084AF532

Alexa Fluor 594 NB110-41084AF594

Alexa Fluor 647 NB110-41084AF647

Alexa Fluor 700 NB110-41084AF700

Alexa Fluor 750 NB110-41084AF750

Allophycocyanin NB110-41084APC

Biotin NB110-41084B

DyLight 350 NB110-41084UV

DyLight 405 NB110-41084V

DyLight 488 NB110-41084G

DyLight 550 NB110-41084R

DyLight 594 NB110-41084DL594

DyLight 650 NB110-41084C

DyLight 680 NB110-41084FR

DyLight 755 NB110-41084IR

FITC NB110-41084F

HRP NB110-41084H

HRP NBP3-09055

Janelia Fluor 525 NB110-41084JF525

Janelia Fluor 549 NB110-41084JF549

Janelia Fluor 585 NB110-41084JF585

Janelia Fluor 635 NB110-41084JF635

Janelia Fluor 646 NB110-41084JF646

Janelia Fluor 669 NB110-41084JF669

PE NB110-41084PE

PerCP NB110-41084PCP

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	NB110-41084AF350
Alexa Fluor 405	NB110-41084AF405
Alexa Fluor 488	NB110-41084AF488
Alexa Fluor 532	NB110-41084AF532
Alexa Fluor 594	NB110-41084AF594
Alexa Fluor 647	NB110-41084AF647
Alexa Fluor 700	NB110-41084AF700
Alexa Fluor 750	NB110-41084AF750
Allophycocyanin	NB110-41084APC
Biotin	NB110-41084B
DyLight 350	NB110-41084UV
DyLight 405	NB110-41084V
DyLight 488	NB110-41084G
DyLight 550	NB110-41084R
DyLight 594	NB110-41084DL594
DyLight 650	NB110-41084C
DyLight 680	NB110-41084FR
DyLight 755	NB110-41084IR
FITC	NB110-41084F
HRP	NB110-41084H
HRP	NBP3-09055
Janelia Fluor 525	NB110-41084JF525
Janelia Fluor 549	NB110-41084JF549
Janelia Fluor 585	NB110-41084JF585
Janelia Fluor 635	NB110-41084JF635
Janelia Fluor 646	NB110-41084JF646
Janelia Fluor 669	NB110-41084JF669
PE	NB110-41084PE
PerCP	NB110-41084PCP

Immunogen	Purified human hemoglobin F of fetal cord blood cell origin.
Specificity	By immunoelectrophoresis and ELISA this antibody reacts specifically with human hemoglobin F. No antibody was detected against hemoglobin A1, A2, S or human serum proteins.
Isotype	IgG
Clonality	Polyclonal
Host	Sheep
Gene	HBG1
Purity	Immunogen affinity purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Fetal Hemoglobin Antibody - BSA Free

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Storage	Store at 4C. Do not freeze.
Buffer	PBS
Preservative	0.09% Sodium Azide
Concentration	1.0 mg/ml
Purity	Immunogen affinity purified

Publications using NB110-41084	Applications	Species
Li C, Shin H, Bhavanasi D et al. Expansion of human hematopoietic stem cells by inhibiting translation bioRxiv 2023-11-30 [PMID: 38077058]
Scott A Peslak, Selami Demirci, Vemika Chandra, Byoung Ryu, Saurabh K Bhardwaj, Jing Jiang, Jeremy W Rupon, Robert E Throm, Naoya Uchida, Alexis Leonard, Khaled Essawi, Aylin C Bonifacino, Allen E Krouse, Nathaniel S Linde, Robert E Donahue, Francesca Ferrara, Matthew Wielgosz, Osheiza Abdulmalik, Nicole Hamagami, Paula Germino-Watnick, Anh Le, Rebecca Chu, Malikiya Hinds, Mitchell J Weiss, Wei Tong, John F Tisdale, Gerd A Blobel Forced enhancer-promoter rewiring to alter gene expression in animal models. Molecular therapy. Nucleic acids 2023-03-14 [PMID: 36852088]
Huang P, Peslak SA, Ren R et al. HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription Nature genetics 2022-09-01 [PMID: 35941187] (FLOW, Human, Mouse)	FLOW	Human, Mouse
Qin K, Huang P, Feng R et al. Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells Nature genetics 2022-05-26 [PMID: 35618846] (FLOW, Human)	FLOW	Human
Huang P, Peslak SA, Lan X et al. HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression Blood 2020-04-16 [PMID: 32299090]
Khandros E, Huang P, Peslak SA, Sharma M Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of F-and A-erythroblasts Blood 2020-01-01 [PMID: 32268371]
Makino T, Haruyama M, Katayama K et al. Phenotypic-screening generates active novel fetal globin-inducers that downregulate Bcl11a in a monkey model Biochem. Pharmacol. 2019-11-18 [PMID: 31751536] (ELISA, Human)	ELISA	Human
Zhang X, Luo YM, Ma YN et al. In vitro maturation of erythroid progenitors from human umbilical cord blood and patterns of globin gene expression: serum from different developmental stage plays important roles in liquid culture. Biochem Biophys Res Commun 2005-10-01 [PMID: 16125140]
Umeda K, Heike T, Yoshimoto M et al. Development of primitive and definitive hematopoiesis from nonhuman primate embryonic stem cells in vitro. Development 2004-04-01 [PMID: 15084470]

Gene Symbol	HBG1
Entrez	3048(Human)
Uniprot	P69892(Human)