ErbB2/Her2 [p Tyr1248] Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. ErbB2 is widely expressed in epithelial cells and has also been found to be over-expressed in a large number of breast carcinomas. Among ErbB family members, ErbB2 is unique in that it has no identified ligands. Rather, ErbB2 heterodimerizes with the other members of the ErbB family (ErbB1 (EGFR), ErbB3, ErbB4) to form higher affinity signaling complexes. Because ErbB3 contains a defective kinase domain, the kinase domain of ErbB2 is responsible for initiating the tyrosine phosphorylation signal through the heterodimeric receptor. It has been found that a discrete three amino acid signal in the ErbB3 cytoplasmic domain is critical for transactivation of ErbB2. Interestingly, this same three amino acid signal has also been found in ErbB1 and ErbB4. Phosphoinositide 3-kinase has been shown to play a role in ErbB2 signal transduction. The cytoplasmic domain of ErbB2 has been shown to associate with beta-catenin and plakoglobin. Human ErbB2 consists of 1255 amino acids (aa) with a 21 aa signal sequence, a 631 aa extracellular domain, a 23 aa transmembrane region, and a 580 aa cytoplasmic domain. ErbB2 can be shed from the cell surface by proteolytic cleavage by an unidentified protease. ErbB2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation (1-10).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Westen Blot, Western Blot.

Showing Publications 1 - 8 of 8.

Publications using AF1768	Applications	Species
Huang, HN;Hung, PF;Chen, YP;Lee, CH; Leucine Zipper Downregulated in Cancer-1 Interacts with Clathrin Adaptors to Control Epidermal Growth Factor Receptor (EGFR) Internalization and Gefitinib Response in EGFR-Mutated Non-Small Cell Lung Cancer International journal of molecular sciences 2024-01-23 [PMID: 38338651] (Westen Blot, Human)	Westen Blot	Human
Moeez Rathore, Wei Zhang, Michel'le Wright, Mehrdad Zarei, Ali Vaziri-Gohar, Omid Hajihassani et al. Liver Endothelium Microenvironment Promotes HER3-mediated Cell Growth in Pancreatic Ductal Adenocarcinoma Journal of Cancer Science and Clinical Therapeutics 1/16/2023 [PMID: 36644317]
Noora Nykänen, Rami Mäkelä, Antti Arjonen, Ville Härmä, Laura Lewandowski, Eileen Snowden et al. Ex Vivo Drug Screening Informed Targeted Therapy for Metastatic Parotid Squamous Cell Carcinoma Frontiers in Oncology 9/16/2021 [PMID: 34604070]
Andrew Baker, Debra Wyatt, Maurizio Bocchetta, Jun Li, Aleksandra Filipovic, Andrew Green et al. Notch-1-PTEN-ERK1/2 signaling axis promotes HER2+ breast cancer cell proliferation and stem cell survival Oncogene 8/1/2018 [PMID: 29743588]
Cancer Genome Atlas Research Network, W Marston Linehan, Paul T Spellman, Christopher J Ricketts, Chad J Creighton, Suzanne S Fei et al. Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma New England Journal of Medicine 1/14/2016 [PMID: 26536169]
Li , Guangyua, Wang , Xiaoqi, Hibshoosh , Hanina, Jin , Cheng, Halmos , Balazs Modulation of ErbB2 blockade in ErbB2-positive cancers: the role of ErbB2 Mutations and PHLDA1. PLoS ONE, 2014-09-19;9(9):e106349. 2014-09-19 [PMID: 25238247] (Western Blot, Human)	Western Blot	Human
Fei Song, Pohung Chiang, Jiajing Wang, John Ravits, Jeffrey A. Loeb Aberrant Neuregulin 1 Signaling in Amyotrophic Lateral Sclerosis Journal of Neuropathology & Experimental Neurology 2/1/2012 [PMID: 22249457]
Wang G, Haile S, Comuzzi B, Tien AH, Wang J, Yong TM, Jelescu-Bodos AE, Blaszczyk N, Vessella RL, Masri BA, Sadar MD Osteoblast-derived factors induce an expression signature that identifies prostate cancer metastasis and hormonal progression. Cancer Res., 2009-04-07;69(8):3433-42. 2009-04-07 [PMID: 19351846] (Western Blot, Human)	Western Blot	Human

Array AF1768

• ErbB2/Her2 Antibodies
• ErbB2/Her2 Antibody Pair
• ErbB2/Her2 Lysate
• ErbB2/Her2 Proteins
• ErbB2/Her2 ELISAs
• ErbB2/Her2 Proteins and Enzymes