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Complement Factor H-related 5/CFHR5 Antibody (390513) [Unconjugated]

 (4 Publications)
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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clone
390513
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price
Carrier Free
MAB3845-SP
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Complement Factor H-related 5/CFHR5 Antibody (390513) [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Complement Factor H-related 5/CFHR5
Glu19-Glu569
Accession # Q9BXR6
Specificity
Detects human Complement Factor H-related 5/CFHR5 in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CFHR5
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunoprecipitation 25 ug/mL
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB3845 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Complement Factor H-related 5/CFHR5 Antibody (390513) [Unconjugated]

  • CFHL5
  • CFHL5factor H-related protein 5
  • CFHR5
  • Complement Factor Hrelated 5
  • Complement Factor H-related 5
  • FHR5
  • FHR-5complement factor H-related protein 5
  • FHR5MGC133240
  • FLJ10549

Background

Complement factor H-related protein 5 (FHR-5 or CFHR5) is a 65 kDa member of the factor H-related protein family.  It is secreted by the liver and circulates either free or bound to HDL.  It is unique among FHR proteins in that it associates with complexes that arise from complement activation.  It promotes C3b cleavage and blocks C3 convertase activity.  Human CFHR5 is 551 amino acids (aa) in length.  It contains nine, 60 aa SUSHI-, or short consensus repeats, plus 18 intrachain disulfide bonds. SUSHI repeats 5-7 (aa 267-444) reportedly mediate CFHR5 binding to CRP and heparin.  The complement interaction site(s) is unknown.  Human CFHR5 shares 64% aa sequence identity with canine CFHR5.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Complement Factor H-related 5/CFHR5 Antibody (MAB3845)(4)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: ELISA, ICC, Mass Spectrometry, Western Blot.


Filter By Application
ELISA
(1)
ICC
(1)
Mass Spectrometry
(1)
Western Blot
(2)
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Human
(2)
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Showing Publications 1 - 4 of 4.
Publications using MAB3845 Applications Species
Iglesias, MJ;Sanchez-Rivera, L;Ibrahim-Kosta, M;Naudin, C;Munsch, G;Goumidi, L;Farm, M;Smith, PM;Thibord, F;Kral-Pointner, JB;Hong, MG;Suchon, P;Germain, M;Schottmaier, W;Dusart, P;Boland, A;Kotol, D;Edfors, F;Koprulu, M;Pietzner, M;Langenberg, C;Damrauer, SM;Johnson, AD;Klarin, DM;Smith, NL;Smadja, DM;Holmström, M;Magnusson, M;Silveira, A;Uhlén, M;Renné, T;Martinez-Perez, A;Emmerich, J;Deleuze, JF;Antovic, J;Soria Fernandez, JM;Assinger, A;Schwenk, JM;Souto Andres, JC;Morange, PE;Butler, LM;Trégouët, DA;Odeberg, J; Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism Nature communications 2023-06-07 [PMID: 37286573] (ELISA, Western Blot, Mass Spectrometry, Human) ELISA, Western Blot, Mass Spectrometry Human
Nóra Garam, Marcell Cserhalmi, Zoltán Prohászka, Ágnes Szilágyi, Nóra Veszeli, Edina Szabó et al. FHR-5 Serum Levels and CFHR5 Genetic Variations in Patients With Immune Complex-Mediated Membranoproliferative Glomerulonephritis and C3-Glomerulopathy Frontiers in Immunology 2021-09-10 [PMID: 34566977]
Chen Q, Manzke M, Hartmann A, Buttner M, Amann K, Pauly D, Wiesener M, Skerka C, Zipfel P Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces. J Am Soc Nephrol, 2015-10-02;27(5):1413-25. 2015-10-02 [PMID: 26432903] (ICC, Western Blot, Human) ICC, Western Blot Human
Csincsi A, Kopp A, Zoldi M, Banlaki Z, Uzonyi B, Hebecker M, Caesar J, Pickering M, Daigo K, Hamakubo T, Lea S, Goicoechea de Jorge E, Jozsi M Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation. J Immunol, 2015-04-08;194(10):4963-73. 2015-04-08 [PMID: 25855355]

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Bioinformatics

Gene Symbol CFHR5
Uniprot