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CBFB Antibody [Biotin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP, WB (-)
Clonality
Polyclonal
Host
Rabbit
Conjugate
Biotin

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CBFB Antibody [Biotin] Summary

Immunogen
The immunogen this antibody was made to, maps to a region between residue 1 and 50 of human Core-Binding Factor, Beta Subunit using the numbering given in entry NP_001746.1 (GeneID 865).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CBFB
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for CBFB Antibody [Biotin]

  • CBFB
  • CBF-beta
  • core-binding factor subunit beta
  • core-binding factor, beta subunit
  • PEA2-beta
  • PEBP2B
  • PEBP2-beta
  • polyomavirus enhancer binding protein 2, beta subunit
  • Polyomavirus enhancer-binding protein 2 beta subunit
  • SL3/AKV core-binding factor beta subunit
  • SL3-3 enhancer factor 1 beta subunit
  • SL3-3 enhancer factor 1 subunit beta
  • SL3-3

Background

The transcription factor Polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (Osteoblast-specific transcription factor), CBFA1 (Core Binding Factor) and AML3 (Acute myeloid leukemia), is composed of two subunits, alpha and beta, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2alpha subunits, PEBP2alphaA, PEBP2alphaB and PEBP2alphaC, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, runt. This region is involved in DNA binding and heterodimerization with the regulatory beta subunit, which facilitates DNA binding of the alpha subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2beta is the target of chromosomal inversion 16 (p13;q22) with the smooth muscle myosin heavy chain, producing a chimeric gene, PEBP2beta/CBFbeta-SMMHC, that is associated with human acute myeloid leukemia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CBFB