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BACE-2 Antibody [Biotin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Sheep
Conjugate
Biotin
Concentration
LYOPH

Order Details

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Catalog# & Conjugate Size Price
Unconjugated
AF4097
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
AF4097
Carrier Free
AF4097
Carrier Free
AF4097-SP
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BACE-2 Antibody [Biotin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human BACE-2
Gly63-Pro466
Accession # Q9Y5Z0.1
Specificity
Detects human BACE‑2 Ectodomain in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human (rh) BACE-1, rhCathepsin D, and rhCathepsin E is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
BACE2
Purity Statement
Antigen Affinity-purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
Readout System
Publications
Read Publication using
BAF4097 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BACE-2 Antibody [Biotin]

  • AEPLC
  • Asp 1
  • ASP1
  • ASP21
  • Aspartic-like protease 56 kDa
  • Aspartyl protease 1
  • BACE2
  • BACE-2
  • beta secretase 2
  • beta-secretase 2
  • beta-site amyloid beta A4 precursor protein-cleaving enzyme 2
  • Beta-site amyloid precursor protein cleaving enzyme 2
  • Beta-site APP cleaving enzyme 2
  • beta-site APP-cleaving enzyme 2
  • beta-site APP-cleaving enzyme 2, EC 3.4.2310ALP5656 kDa aspartic-like protease
  • CEAP1
  • Down region aspartic protease
  • Down syndrome region aspartic protease
  • DRAPBAE2
  • EC 3.4.23
  • EC 3.4.23.45
  • memapsin-1
  • Membrane-associated aspartic protease 1
  • theta-secretase
  • transmembrane aspartic proteinase Asp1

Background

BACE-2 ( beta -site APP cleaving enzyme 2; also ASP-1 and Memapsin-1) is a 73‑75 kDa member of the peptidase A1 family. It is expressed both inside and outside the CNS and is classified as a Golgi aspartyl protease. Its status as a beta -secretase is unclear. If it has physiological activity, it may be associated with glia. Mature BACE-2 is a 456 amino acid (aa) type I transmembrane glycoprotein. It contains a 411 aa extracellular domain (aa 63‑473) that has two catalytic residues (Asp93 and Asp289). Two potential splice forms exist; one shows a deletion of aa’s 329‑378, while a second shows an 18 aa substitution for aa’s 380‑518. Over aa 63‑466, human BACE-2 shares 92% aa sequence identity with mouse BACE‑2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for BACE-2 Antibody (BAF4097)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA Development.


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Bioinformatics

Gene Symbol BACE2
Uniprot