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Negative Regulation Of Angiogenesis Pathway Bioinformatics

Angiogenesis is the process of the formation of new blood vessels from those that already exist. Angiogenesis is an important function in the oxygenation of tissues, and can help in various functions including wound healing and the treatment of vascular diseases such as heart disease, high blood pressure, and diabetes. An abnormal rate of angiogenesis, however, can cause many problems including the proliferation of cancerous tumors, diabetic ulcers, and cardiovascular diseases. Many scientists have studied factors of angiogenesis, and treatments have been created that work in the negative regulation of angiogenesis, including sphingosine-1 phosphate and TCF8. Consequently, researchers are also looking to inhibit proteins that facilitate angiogenesis, such as VEGF.

Top Research Reagents

We have 2663 products for the study of the Negative Regulation Of Angiogenesis Pathway that can be applied to Chromatin Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

Presenilin-1 Antibody (APS 18)
NB100-74510
Western Blot: Presenilin-1 Antibody (APS 18) [NB100-74510] - Analysis of THP-1 cell lysate.Immunocytochemistry/Immunofluorescence: Presenilin-1 Antibody (APS 18) [NB100-74510] - Analysis of Presenilin 1 using Presenilin 1 Monoclonal antibody (APS 18) shows staining in A2058 melanoma cells. Presenilin 1 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing Presenilin 1 at a dilution of 1:20-1:100 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

     1 Review

5 Publications
ARNT/HIF-1 beta Antibody (H1beta234) - BSA Free
NB100-124
Western Blot: ARNT/HIF-1 beta Antibody (H1beta234) - BSA Free [NB100-124] - ARNT/HIF-1 beta Antibody (H1beta234) [NB100-124] - Western Blot analysis with ARNT/HIF-1 beta antibody (H1beta234) [NB100-124], theoretical molecular weight 86.6 kDa. Expression of CD44 mRNA in genetically engineered MDA-MB-231 cells. (A) Immunoblot analysis of HIF-1A or HIF-2A expression in whole cell extracts from MDA-MB-231 cells stably expressing EV, HIF-1A-shRNA or HIF-2A-shRNA under normoxia or in response to 4 h treatment with 200 uM CoCl2. HIF-1B expression was used as a loading control. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0044078) licensed under a CC-BY license.Western Blot: ARNT/HIF-1 beta Antibody (H1beta234) [NB100-124] - HIF was not the only factor stabilizing activated EGFR in VHL-deficient ccRCC cells. A. Western blot analysis of 786-VHL and 786-mock cells stably expressing shRNA constructs. For HIF2A (NB100-480) and ARNT/HIF-1 beta antibody (H1beta234)[NB100-124] analysis, nuclear extracts were generated and analyzed. Anti-HA blot detected HA-VHL. Means and SDs of three separate experiments were shown. Theoretical molecular weight for ARNT/HIF-1 beta is 86.6 kDa, observed molecular weight ~90 kDa. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0023936) licensed under a CC-BY license.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, GS, IB

     4 Reviews

106 Publications
SIM2 Antibody
NBP1-68864
Western Blot: SIM2 Antibody [NBP1-68864] - (0.5ug/ml) staining of fetal Mouse kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Goat Polyclonal
Species Mouse
Applications WB, PEP-ELISA

1 Publication
HIF-3 alpha Antibody
NBP1-89977
Immunohistochemistry-Paraffin: HIF-3 alpha Antibody [NBP1-89977] - Staining of human skin shows moderate to strong cytoplasmic and nuclear positivity in squamous epithelial cells.Immunohistochemistry-Paraffin: HIF-3 alpha Antibody [NBP1-89977] - Staining of human Fallopian tube shows moderate to strong nuclear and cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

HIF-1 alpha Antibody (H1alpha67)
NB100-105
HIF-1 alpha induction by CoCl2 on Caki-1 cell lysate. WB image submitted by a verified customer review.HIF-1 alpha was detected in immersion fixed DFO treated Hela cells (left) but was not detected in HIF-1 knockout HeLa cells (right) using Mouse Anti-human HIF-1 alpha monoclonal antibody (Catalog # NB100-105) at 25 ug/mL for 3 hours at room temperature. Cells were stained using a NorthernLights (TM) 557-conjugated Donkey Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to nuclei.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ChIP

     45 Reviews

1040 Publications
Neuropilin-1 Antibody [Unconjugated]
AF566
Western blot shows 25 ng of Recombinant Mouse Neuropilin-1 (Catalog # <a class=bEnd.3 mouse endothelioma cell line was stained with Goat Anti-Rat Neuropilin‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF566, filled histogram) or isotype control antibody (Catalog # <a class=

Goat Polyclonal
Species Mouse, Rat
Applications WB, Flow, IHC

     10 Reviews

108 Publications
EphB2 Antibody [Unconjugated]
AF467
Western blot shows 25 ng of Recombinant Human EphB2 Fc Chimera (Catalog # <a class=COLO 205 human colorectal adenocarcinoma cell line was stained with Goat Anti-Human/Mouse EphB2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF467, filled histogram) or isotype control antibody (Catalog # <a class=

Goat Polyclonal
Species Human, Mouse
Applications WB, Simple Western, Flow

     5 Reviews

62 Publications
ERK2 Antibody [Unconjugated]
AF1230
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, MCF-7 human breast cancer cell line, U937 human histiocytic lymphoma cell line, PC-12 rat adrenal pheochromocytoma cell line, and NIH-3T3 mouse embryonic fibroblast cell line. PVDF membrane was probed with 0.1 µg/mL of Rabbit Anti-Human/Mouse/Rat ERK2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1230) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # <a class= ERK2 was detected in immersion fixed paraffin-embedded sections of human breast using Rabbit Anti-Human/Mouse/Rat ERK2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1230) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody (Catalog # <a class=

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, KO

3 Publications
NELL1 Antibody
AF7109
Western blot shows lysates of Neuro-2A mouse neuroblastoma cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Mouse NELL1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7109) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <a class=NELL1 was detected in immersion fixed frozen sections of mouse embryo (13 d.p.c.) using Sheep Anti-Mouse NELL1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7109) at 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <a class=

Sheep Polyclonal
Species Mouse
Applications WB, IHC

Chondromodulin-1/LECT1 Antibody (394002) [Unconjugated]
MAB41681

Mouse Monoclonal
Species Human
Applications WB

2 Publications
Serpin F1/PEDF [Biotin]
DY1177-05
N/A Serpin F1/PEDF [Biotin]


Species Human
Applications ELISA

19 Publications
VEGF [HRP]
DVE00
N/A VEGF [HRP]N/A VEGF [HRP]


Species Human
Applications ELISA

681 Publications
FGF basic/FGF2/bFGF [Unconjugated]
233-FB


Species Human
Applications BA

546 Publications
VEGFR1/Flt-1 [HRP]
DVR100C
N/A VEGFR1/Flt-1 [HRP]N/A VEGFR1/Flt-1 [HRP]


Species Human
Applications ELISA

87 Publications
Vasohibin Antibody (4A3)
H00022846-M05
Western Blot: Vasohibin Antibody (4A3) [H00022846-M05] - Analysis of VASH1 expression in HepG2 (Cat # L019V1).Immunohistochemistry-Paraffin: Vasohibin Antibody (4A3) [H00022846-M05] - Analysis of monoclonal antibody to VASH1 on formalin-fixed paraffin-embedded human salivary gland. Antibody concentration 3 ug/ml

Mouse Monoclonal
Species Human
Applications WB, ELISA, IHC

5 Publications

Related Genes

The Negative Regulation Of Angiogenesis Pathway has been researched against:

Related Pathways

The Negative Regulation Of Angiogenesis Pathway has been linked to:

Related Diseases

The Negative Regulation Of Angiogenesis Pathway has been studied in relation to diseases such as:

Related PTMs

The Negative Regulation Of Angiogenesis Pathway has been studied in relation to posttranslational modifications (PTMs) including: