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Endocardial Cushion Morphogenesis Pathway Bioinformatics

Disease and disorder research has been conducted in relation to the Endocardial Cushion Morphogenesis Pathway and Congenital Heart Defects, Congenital Abnormality, Endocardial Cushion Defects, Regurgitation, Developmental Delay (disorder). The study of the Endocardial Cushion Morphogenesis Pathway has been mentioned in research publications which can be found using our bioinformatics tool below. The Endocardial Cushion Morphogenesis Pathway has been researched in relation to Heart Development, Heart Morphogenesis, Endocardial Cushion Development, Cell Activation, Endothelial Cell Activation. The Endocardial Cushion Morphogenesis Pathway complements our catalog of research reagents including antibodies and ELISA kits against PERIOSTIN, HEREGULIN, E14, PROTEIN 3, ACTA2.

Top Research Reagents

We have 3442 products for the study of the Endocardial Cushion Morphogenesis Pathway that can be applied to Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

NOD2 Antibody (2D9) - BSA Free
NB100-524
Western Blot: NOD2 Antibody (2D9) [NB100-524] - HCMV infection induces NOD2 mRNA and protein in HFFs and U373 cells. E. U373 glioma cells were infected with HCMV Towne strain and levels of NOD1, NOD2 and GAPDH mRNAs were measured by qRT-PCR at indicated time points. F. HFFs were infected with HCMV (Towne) at MOI of 1 PFU/cell and levels of NOD2 protein and B-actin were determined 48 and 72 hpi. G. HFFs were infected with HCMV (Towne) strain at MOI of 0.03 or 3 PFU/cell and levels of NOD2 protein and B-actin were determined at 48 hpi. Quantitative data represent mean values (+/-SD) of triplicate determinations from three independent experiments (*p<0.05, **p<0.01, ***p<0.001, one-way ANOVA test). Image collected and cropped by CiteAb from the following publication (//doi.org/10.1371/journal.pone.0092704.g001) licensed under a CC-BY license.Immunohistochemistry-Frozen: NOD2 Antibody (2D9) [NB100-524] - Overlay of NOD2-DyLight 488 (green) with phase contrast of murine colon. Image from verified customer review.

Mouse Monoclonal
Species Human, Mouse
Applications WB, Flow, ICC/IF

     1 Review

26 Publications
NFATC1/NFAT2 Antibody
NB100-56732
Western Blot: NFATC1/NFAT2 Antibody [NB100-56732] - Immortalized mouse podocytes. Image from verified customer review.Immunocytochemistry/Immunofluorescence: NFATC1/NFAT2 Antibody [NB100-56732] - NFAT2 antibody was tested in Raw 246.7 cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and DyLight 550 (red). Image objective 40x. An antibody dilution of 1:10 was used.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, ICC/IF

     2 Reviews

4 Publications
SLC22A3 Antibody
NBP1-83976
Immunocytochemistry/Immunofluorescence: SLC22A3 Antibody [NBP1-83976] - Immunofluorescent staining of human cell line A549 shows localization to cytosol & vesicles.Immunohistochemistry-Paraffin: SLC22A3 Antibody [NBP1-83976] - Staining of human liver shows weak to moderate cytoplasmic positivity in hepatocytes.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

1 Publication
Arylsulfatase D Antibody
NBP1-87486
Western Blot: Arylsulfatase D Antibody [NBP1-87486] - Analysis in control (vector only transfected HEK293T lysate) and ARSD over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: Arylsulfatase D Antibody [NBP1-87486] - Staining of human fallopian tube shows strong cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

MEKK3 Antibody (576240) [Unconjugated]
MAB6095
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, Daudi human Burkitt's lymphoma cell line, and A431 human epithelial carcinoma cell line. PVDF Membrane was probed with 1 µg/mL of Mouse Anti-Human MEKK3 Monoclonal Antibody (Catalog # MAB6095) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <a class=Western blot shows lysates of HeLa human cervical epithelial carcinoma parental cell line and MEKK3 knockout HeLa cell line (KO). PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human MEKK3 Monoclonal Antibody (Catalog # MAB6095) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <a class=

Mouse Monoclonal
Species Human
Applications WB, KO

COUP-TF II/NR2F2 Antibody (H7147) [Unconjugated]
PP-H7147-00
Reduction of COUP-TFII or nucleolin decreases RAR beta 2 transcription in MCF-7 cells.MCF-7 (A) and T47D (B) cells were transfected with control siRNA or an siRNA targeting nucleolin for 48 h. T47D cells were treated with EtOH or 1 µM atRA for 24 h. Q-PCR for nucleolin (NCL) and RARB2. Values are the average of triplicates. C, Western blot showing COUP-TFII and RAR beta 2 expression after transfection with siCOUP-TFII. Values are relative to beta -actin. MCF-7 were transfected with siControl or siCOUP-TFII for 48 h and treated with 1 µM atRA for 6 h. Q-PCR was also performed for RRIG1. P<0.001 * versus control or ** versus atRA. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0038278), licensed under a CC-BY license. Not internally tested by R&D Systems.Loss of miR-101 promotes cancer metastasis through de-repression of COUP-TFII expression.(a) LNCaP and PC3 cells were individually treated with 50 nM of miR-101 and miR-27a mimic for 48 h and then invasion assays were performed for an additional 16 h (n=3). *P<0.05 (two-sided Student's t-test) compared with the control group. (b) Representative western blot showed the levels of COUP-TFII, E-cadherin, vimentin and beta -actin in PC3 cells stably knocked down by COUP-TFII. (c) LNCaP and PC3 cells stably knocked-down of COUP-TFII were used to perform cell invasion assay. Invaded cells were stained and counted (lower panel) (n=3). Representative western blot showed the knockdown efficiency of COUP-TFII (upper panel). *: P<0.05 (two-sided Student's t-test) compared with control group. (d) PC3 cells carrying an inducible miR-101 in the absence and presence of doxycycline, and re-expression of COUP-TFII were used to perform invasion assays (n=3). Representative western blot showed the levels of COUP-TFII and beta -actin (left). Invaded cells were counted and results are shown in the right panel. *: P<0.05 (two-sided Student's t-test) (e) 22RV-1 cells were treated with miR-101 inhibitor (antisense RNA) in conjunction with knockdown of COUP-TFII and used for invasion assays (n=3). Representative western blot show the levels of COUP-TFII and beta -actin (left). Invaded cells were counted and result is shown in the right panel. *: P<0.05 (two-sided Student's t-test). (f) LNCaP cells containing a construct with inducible expression of COUP-TFII shRNA and constructs expressing with anti-miR-101 and anti-mir-27a were orthotopically injected into NOD-SCID mouse prostate. In addition these cells also contain a luciferase reporter to detect cancer cells. After the tumour size was bigger than 50 mm3, drinking water with or without doxycycline (1 mg ml−1) was given to the mice for 6 weeks to induce the COUP-TFII shRNA to repress COUP-TFII expression. Representative bioluminescence results show the status of tumour growth in different groups. (g) Quantification result of luminance from IVIS (control: n=5; anti-miR-101/27a(−): n=6; anti-miR-101/27a(+): n=7. *: P<0.05 (two-sided Student's t-test). (h) Immunohistochemical stain showed the metastatic tumour cells located in the mouse lymph node are positive for AR. Scale bar: 100 μM (low power); and 200 μM (high power). SCID, severe combined immunodeficient. Image collected and cropped by CiteAb from the following publication (https://www.nature.com/articles/ncomms11418), licensed under a CC-BY license. Not internally tested by R&D Systems.

Mouse Monoclonal
Species Human
Applications WB, IHC, IP

     3 Reviews

46 Publications
Hyaluronan synthase 2 Antibody (4E7) - BSA Free
NBP2-37446
Western Blot: Hyaluronan synthase 2 Antibody (4E7) [NBP2-37446] - Western blot analysis using HAS2 mouse mAb against NTERA-2 (1), HEK293 (2) cell lysate.Immunocytochemistry/Immunofluorescence: Hyaluronan synthase 2 Antibody (4E7) [NBP2-37446] - Immunofluorescence analysis of HeLa cells using HAS2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

2 Publications
TGF-beta 1 [Unconjugated]
7754-BH/CF
Recombinant human TGF-beta 1 (<a class=NoLineLink href=


Species Human
Applications BA

53 Publications
CTLA-4 [Unconjugated]
7268-CT
Recombinant Human CTLA-4 Fc Chimera (Catalog # 7268-CT) inhibits IL-2 secretion by stimulated Jurkat human acute Tcell leukemia cells. The ED<sub>50</sub> for this effect is 0.03-0.15 μg/mL whenstimulated with 1 μg/mL Recombinant Human B7‑1/CD80 Fc Chimera (Catalog # <a class=


Species Human
Applications BA

3 Publications
ErbB2/Her2 [Unconjugated]
1129-ER
1 μg/lane of Recombinant Human ErbB2 Fc Chimera was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing major bands at 125-130 kDa and  220-250 kDa, respectively.Recombinant human ErB2 / Her2 (<a class=


Species Human
Applications BA

58 Publications
TGF-beta 3 [Unconjugated]
243-B3
As an alternative, please consider our next generation CHO-drived Recombinant Human TGF‑ beta 3 (<a class=


Species Human
Applications BA

123 Publications
ErbB3/Her3 Antibody (66223) [Unconjugated]
MAB3481
Recombinant Human NRG1‑1 beta 1/HRG1‑1 beta 1 (Catalog # <A class=NoLineLink href=

Mouse Monoclonal
Species Human
Applications Flow, CyTOF-ready, ELISA(Cap)

21 Publications
FoxP1 Antibody (JC12) - BSA Free
NB100-65125
Western Blot: FOXP1 Antibody (JC12) [NB100-65125] - Western blot analysis of resonicated MCF7 cell lysate (A) and MCF7 cell lysate (B) using FOXP1 antibody at 2 ug/ml.Immunocytochemistry/Immunofluorescence: FOXP1 Antibody (JC12) [NB100-65125] - FOXP1 antibody was tested at 1:25 in MCF-7 cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). Image objective 40x.

Mouse Monoclonal
Species Human, Mouse
Applications WB, Flow, ICC/IF

8 Publications
SOX4 Antibody (CL5665)
NBP2-61421
Immunocytochemistry/Immunofluorescence: SOX4 Antibody (CL5665) [NBP2-61421] - Staining of SH-SY5Y cells using the Anti-SOX4 monoclonal antibody, showing specific staining in the nucleoplasm in green. Microtubule and nuclear probes are visualized in red and blue, respectively (where available).Immunohistochemistry-Paraffin: SOX4 Antibody (CL5665) [NBP2-61421] - Staining of human endometrium shows moderate to strong nuclear positivity in stromal cells.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications ICC/IF, IHC, IHC-P

ITK Antibody
NB100-807
Western Blot: ITK Antibody [NB100-807] - Staining of Jurkat nuclear cell lysate with antibody at 1 ug/mL (A) and negative control Human parathyroid gland (B) (35 ug protein in RIPA buffer). Detected by chemiluminescence.Immunocytochemistry/Immunofluorescence: ITK Antibody [NB100-807] - Immunofluorescence analysis of paraformaldehyde fixed Jurkat cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing strong cytoplasmic and weak nuclear staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL).

Goat Polyclonal
Species Human
Applications WB, ICC/IF, PEP-ELISA

3 Publications

Related Genes

The Endocardial Cushion Morphogenesis Pathway has been researched against:

Related Pathways

The Endocardial Cushion Morphogenesis Pathway has been linked to:

Related Diseases

The Endocardial Cushion Morphogenesis Pathway has been studied in relation to diseases such as:

Related PTMs

The Endocardial Cushion Morphogenesis Pathway has been studied in relation to posttranslational modifications (PTMs) including: