PARP Products

Description

Poly (ADP-ribose) polymerase (PARP) is protein family primarily invloved in DNA repair and programmed cell death. PARP proteins are activated in response to DNA single strand breaks (SSBs). Upon SSB detection, PARP binds the DNA and synthesizes a PAR chain at the damaged site, which then signals the initiation of DNA repair by other enzymes such as XRCC1, DNA ligase III and DNA polymerase beta. After repair, the PAR chains are degraded via PAR glycohydrolase.

PARP is inactivated by caspase cleavage, leading to a programmed cell death pathway.

Bioinformatics

Uniprot	AAH37545 Human ABM85752.1 Human NP_001609 Human NP_031441 Mouse P09874 Human P27008 Rat
Product By Gene ID	142
Alternate Names	ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) ADPRT 1 ADPRTADP-ribosyltransferase NAD(+) EC 2.4.2 EC 2.4.2.30 NAD(+) ADP-ribosyltransferase 1 PARP apoptosis PARP-1 PARPADPRT1 poly (ADP-ribose) polymerase 1 poly (ADP-ribose) polymerase family, member 1 poly [ADP-ribose] polymerase 1 poly(ADP-ribose) polymerase poly(ADP-ribose) synthetase poly(ADP-ribosyl)transferase Poly[ADP-ribose] synthase 1 PPOLpADPRT-1

Research Areas for PARP

Find related products by research area and learn more about each of the different research areas below.

Base Excision Repair
Cancer
Core ESC-Like Genes
DNA Repair
Hypoxia
Phospho-Specific
Stem Cell Markers
Tumor Suppressors

Related PARP Blog Posts

Check out the latest blog posts on PARP.

Caspase 3 - a Reliable Marker for Index of Apoptosis Induction Caspase-3 is one of the most important players in apoptosis signaling. It is synthesized as an inactive 32 kDa pro-enzyme and upon direct activation by Caspase-8, -9 or -10, it gets processed into its active forms, the p17-20 and p10-12 subunits. T...    Read more.

The role of PARP-1 in the repair of single stranded break (SSB) PARPs (poly ADP ribose polymerases) are DNA repair enzymes that promote single stranded break (SSB) repair by binding to DNA at the sites of SSBs and recruiting repair machinery. In humans, the PARP superfamily consists of 17 members, of which five...    Read more.

What are the major differences between Apoptosis, Necroptosis & Autophagy? Apoptosis is a form of programmed cell death which is mediated by cysteine proteases called caspases. It is an essential phenomenon in the maintenance of homeostasis and growth of tissues, and it also plays a critical role in immune response. The ...    Read more.

PARP Antibody Assays aid both Apoptosis and Cancer Research The PARP (Poly(ADP-ribose) polymerase) protein is a zinc-dependant nuclear enzyme whose main role is to detect and repair DNA single-strand breaks (SSB). However, PARP antibody research has revealed there are at least 17 PARP proteins, which also play...    Read more.

Caspase 7: The Cell's Suicide Switch Caspase 7 (also known as CASP7, Mch3, ICE-LAP3, CMH-1) is a member of caspase family of cysteine proteases. It is an apoptosis-related cystein peptidase encoded by the CASP7 gene in humans. CASP7 homologous sequences have been identified in nearly all...    Read more.

Using CometChip to Characterize Extracellular Regulators of DNA Repair: Does CD73 Levels in Cancer Cells Affect DNA Repair by Regulating Levels of Intracellular NAD+? By Natalia Gurule, PhD Historically, DNA repair pathways have been viewed from a tumor cell centric vantage point. Currently, the tumor microenvironment (TME) is recognized as having the potential to be a s...    Read more.

NPC1: A Potential Target For Triple-Negative Breast Cancer By Natalia Gurule, PhD Breast Cancer is a Heterogeneous DiseaseBreast cancer is the most frequently identified malignancy in women, accounting for 30% of diagnosed cases of cancer in women in the US annuall...    Read more.

Caspase 7 - A key effector of the apoptotic pathway Caspase-7 is an effector caspase with important roles in mediating cell death signaling. As an effector caspase, caspase-7 is cleaved and activated by initiator caspases such as caspase-1 (1). Like other caspase family proteins, caspase-7 contains a...    Read more.

Read more PARP related blogs.