Species: Hu
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Host: Sheep Polyclonal
Species: Hu, Mu, Rt, Ca
Applications: WB, ELISA
Host: Goat Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
Gab2 (Grb2-associated binder-2) is an adaptor protein involved in numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs), growth factors and cytokines. Gab2 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors as well as B and T cell antigen receptors; Gab2 acts as a docking protein for several SH2-containing proteins (1-3). Upon tyrosine phosphorylation, Gab2 interacts with SHP2 tyrosine phosphatase and GRB2 adaptor protein PI3-kinase, CrkL and SHC (4-5).
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
9846 |
| Alternate Names |
- GRB2-associated binding protein 2
- GRB2-associated-binding protein 2
- Growth factor receptor bound protein 2-associated protein 2
- KIAA0571GRB2-associated binder 2
- pp100
|
Research Areas for GAB2
Find related products by research area and learn more about each of the different research areas below.
Cancer
Related GAB2 Blog Posts
Check out the latest blog posts on GAB2.
CD19: An Undoubted Biomarker for B Cells
CD19 is a cell surface protein member of the large immunoglobulin superfamily that complexes with CD21, CD81, and CD225 in the membrane of mature B-cells. A major function of CD19 is to assemble with the antigen receptor of B-lymphocytes to decrease t... Read more.
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