COX-2 Products

Description

COX2 (Cyclooxygenase 2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.

Bioinformatics

Entrez	19225 Mouse 29527 Rat 5743 Human
Uniprot	AAH13734.1 Human NP_000954 Human NP_000954. Human NP_000954.1 Human P35354 Human P35355 Rat
Product By Gene ID	5743
Alternate Names	COX-2 COX2cyclooxygenase 2b cyclooxygenase-2 Cyclooxygenase-2 EC 1.14.99 EC 1.14.99.1 GRIPGHS hCox-2 PGG/HS PGH synthase 2 PGHS-2 PHS II PHS-2 prostaglandin G/H synthase 2 prostaglandin G/H synthase and cyclooxygenase Prostaglandin H2 synthase 2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase andcyclooxygenase) Prostaglandin-endoperoxide synthase 2

Research Areas for COX-2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Biology
Cellular Markers
Cytokine Research
Hypoxia
Lipid and Metabolism
Phospho-Specific
Signal Transduction

Related COX-2 Blog Posts

Check out the latest blog posts on COX-2.

Increased wild type FUS levels in ALS patients lead to a toxic microenvironment and motor neuron neurodegeneration By Michalina Hanzel, PhDFUS mutations in Amyotrophic Lateral SclerosisFused in sarcoma (FUS) is a ribonucleoprotein that continuously shuttles between the nucleus and the cytoplasm to regulate pre-mRNA splicing, mRN...    Read more.

Inhibitor kappa B-alpha (IkappaB-alpha) The transcription factor nuclear factor kappa beta (NFkB) is highly regulated by triggers such as stress, free-radicals, UV light, and hypoxia. NFkB is one of the fastest responding transcription factors in humans. The NFKB signaling pathway is ess...    Read more.

SUCNR1/GPR91 - a potential role in renovascular hypertension SUCNR1 is the cognate receptor for the Kreb's citric acid cycle intermediate succinate. It is of interest to scientists because it is involved in not only energy metabolism but possibly also in renovascular hypertension, a condition linked to diabe...    Read more.

Immune Cell Metabolic Flux Influences Type I Diabetes By Hunter MartinezWhat is Immunometabolism?It is well established that abnormal metabolic environments can be a risk factor for disease development. One characteristic example is the role of dyslipidemia (high lev...    Read more.

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