ZMPSTE24 Products

Description

ZMPSTE24, also known as FACE1, is a zinc metalloprotease involved in the post-translational processing of Lamin A/C precursors. Specifically, ZMPSTE-24 proteolytically removes the C-terminal three residues of the farnesylated Lamin proteins.

FACE-1 is widely expressed, with the highest levels found in the kidney, prostate, testis and ovary.

Mutations in ZMPSTE24 have been associated with human diseases such as mandibuloacral dysplasia with type B lipodystrophy (MADB) and lethal tight skin contracture syndrome (LTSCS), often due to the accumulation of LMNA precursors. It is theorized that ZMPSTE24 may play an important role in human ageing, based on its association with LMNA.

Bioinformatics

Entrez	10269 Human 230709 Mouse
Uniprot	AAH37283.1 Human FAC1_HUMAN Human NP_005848.2 Human O75844 Human
Product By Gene ID	10269
Alternate Names	zona pellucida binding protein 2 zona pellucida-binding protein 2 ZPBP-like protein ZPBPLMGC41930

Research Areas for ZMPSTE24

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cell Biology
Cytoskeleton Markers
Extracellular Matrix
Signal Transduction
Ubiquitin Proteasome Pathway

Related ZMPSTE24 Blog Posts

Check out the latest blog posts on ZMPSTE24.

ZMPSTE24 Mutations, Lamin A Processing & Laminopathies ZMPSTE24 (FACE-1, CAAX prenyl protease 1 homolog) is a membrane associated zinc metalloprotease of the peptidase M48A family. It's catalytic activity can be defined as the peptide bond hydrolyzed in the sequence -C-|-A-A-X in which C is an S-isoprenyl...    Read more.

Read more ZMPSTE24 related blogs.