Uromodulin Products

Description

Uromodulin encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq]

Bioinformatics

Entrez	7369 Human
Uniprot	AAH35975 Human AAH35975.1 Human NP_001008390 Human NP_001008390.1 Human P07911 Human
Product By Gene ID	7369
Alternate Names	ADMCKD2 FJHN HNFJ HNFJ1 MCKD2 Tamm-Horsfall glycoprotein Tamm-Horsfall urinary glycoprotein THGP THP uromodulin (uromucoid, Tamm-Horsfall glycoprotein) uromodulin uromucoid

Research Areas for Uromodulin

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Cell Cycle and Replication