Species: Hu
Applications: WB, ELISA, KD
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: AC
Description
Topo III beta encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.
Bioinformatics
| Entrez |
Mouse
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
8940 |
| Alternate Names |
- DNA topoisomerase 3-beta-1
- DNA topoisomerase III beta-1
- EC 5.99.1.2
- FLJ39376
- TOP3B1
- topoisomerase (DNA) III beta
- topoisomerase III beta
|
