SSX2 Products

Description

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene.

Bioinformatics

Entrez	6757 Human
Uniprot	AAH02818 Human AAH02818.1 Human AAH16957 Human NM_003147 Human NM_175698 Human NP_003138 Human Q16385 Human
Product By Gene ID	6757
Alternate Names	Cancer/testis antigen 5.2 cancer/testis antigen family 5, member 2a CT5.2a HD21 HOM-MEL-40 MGC119055 MGC15364 MGC3884 protein SSX2 sarcoma, synovial, X-chromosome-related 2 SSX SSX2A SSX2B synovial sarcoma, X breakpoint 2B synovial sarcoma, X breakpoint 2CT5.2 Tumor antigen HOM-MEL-40

Research Areas for SSX2

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Cancer