SP17 Products

Description

SP17 encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.

Bioinformatics

Entrez	53340 Human
Uniprot	NM_017425 Human NP_059121 Human NP_059121.1 Human Q15506 Human
Product By Gene ID	53340
Alternate Names	Cancer/testis antigen 22 CT22SP17-1 Sp17-1 SP17sperm surface protein Sp17 sperm autoantigenic protein 17Sperm protein 17