SH3BP2 Products

Description

The protein encoded by the SH3BP2 gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq)

Bioinformatics

Entrez	6452 Human
Uniprot	AAH22996 Human AAH22996.1 Human NM_003023 Human NP_001116153 Human P78314 Human
Product By Gene ID	6452
Alternate Names	Abl-SH3 binding protein 2 Cherubism CRBM CRPM FLJ42079 FLJ54978,3BP-2,3BP2 RES4-23 SH3 domain-binding protein 2 SH3-domain binding protein 2 TNFAIP3 interacting protein 2

Research Areas for SH3BP2

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Phospho-Specific
Signal Transduction