Serpin A8/Angiotensinogen Products

Description

Angiotensin II is encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Bioinformatics

Entrez	11606 Mouse 183 Human 24179 Rat
Uniprot	AAH11519 Human AAH11519.1 Human NM_000029 Human P01019 Human
Product By Gene ID	183
Alternate Names	alpha-1 antiproteinase, antitrypsin angiotensin II angiotensinogen (serpin peptidase inhibitor, clade A, member 8) angiotensinogen ANHU FLJ92595 FLJ97926 pre-angiotensinogen serine (or cysteine) proteinase inhibitor Serpin A8 SERPINA8angiotensin I

Research Areas for Serpin A8/Angiotensinogen

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Lipid and Metabolism