RBX1 Products

Description

ROC1 is a component of the SCF (SKP1-CUL1-F-box protein) and the CBC(VHL) (CUL2-elonging BC-VHL) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. ROC1 appears to recruit the E2 ubiquitination enzyme through the RING-type zinc finger in a manner similar to CDC34, and brings it into close proximity to the substrate. The RING-type zinc finger domain is essential for ubiquitin ligase activity. ROC1 probably also stimulates CDC34 autoubiquitination and promotes the neddylation of CUL1 and probably CUL2. ROC1 has a cytoplasmic and nuclear localization and is widely expressed in most tissues.

Bioinformatics

Entrez	56438 Mouse 9978 Human
Uniprot	AAH01466 Human NM_014248 Human NP_055063 Human P62877 Human
Product By Gene ID	9978
Alternate Names	BA554C12.1 EC 6.3.2.- FLJ60363 MGC13357 Protein ZYP Rbx1 Regulator of cullins 1 RING box protein 1 RING finger protein 75 ring-box 1 ring-box 1, E3 ubiquitin protein ligase RING-box protein 1 RNF75MGC1481 ROC1E3 ubiquitin-protein ligase RBX1 ZYP protein

Research Areas for RBX1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Hypoxia
Neuroscience
Wnt Signaling Pathway
Zinc Finger