PRAME Products

Description

PRAME encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Recent data from Epping et.al., (Cell, Vol. 122: 835) suggest that overexpression of PRAME frequently observed in human cancers confers growth or survival advantages by antagonizing RAR signaling.

Bioinformatics

Entrez	23532 Human
Uniprot	AAH39731 Human NM_006115 Human NM_206954 Human NM_206955 Human NP_006106.1 Human NP_996836 Human NP_996839 Human P78395 Human
Product By Gene ID	23532
Alternate Names	cancer/testis antigen 130 MAPEOIP4CT130 melanoma antigen preferentially expressed in tumors OIP-4 Opa-interacting protein 4 Opa-interacting protein OIP4 preferentially expressed antigen in melanoma Preferentially expressed antigen of melanoma

Research Areas for PRAME

Find related products by research area and learn more about each of the different research areas below.

Cancer