Species: Hu, Rt, Pm
Applications: WB, ELISA, Flow, ICC/IF, IHC, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: WB, ELISA, Flow, ICC/IF, IHC, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, Func, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups (1). Phospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. PLC-gamma 1 also has mitogenic activity upon growth-factor-dependent tyrosine phosphorylation; however, this activity is not dependent on the phospholipase activity of PLC-gamma 1, but requires an SH3 domain (2). Also, results indicate a lipase-independent role of PLC-gamma in the physiological agonist-induced activation of Ca2+ entry (3).
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
5335 |
| Alternate Names |
- EC 3.1.4.11
- gamma 1 (formerly subtype 148)
- monophosphatidylinositol phosphodiesterase
- NCKAP3,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
- phosphatidylinositol phospholipase C
- phosphoinositidase C
- phosphoinositide phospholipase C
- Phosphoinositide phospholipase C-gamma-1
- phospholipase C, gamma 1
- phospholipase C-148
- Phospholipase C-gamma-1
- Phospholipase C-II
- PLC11-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1
- PLC148
- PLC-148
- PLC-gamma-1
- PLC-II1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
- triphosphoinositide phosphodiesterase
|
